博导
王辉
姓名:王辉
职称:研究员
职务:
所在学系:牙周科
研究生导师类别:博导
联系方式:hwang02@scu.edu.cn
研究领域:牙周免疫、克隆性造血、训练免疫
个人简介
国家级高层次人才计划(青年项目)、四川大学第十批“双百人才工程” 入选者。2014年毕业于复旦大学上海医学院获得病原生物学博士学位,随后在美国宾夕法尼亚大学牙医学院从事博士后研究。主要研究方向为:牙周炎的免疫学发生机制、训练免疫在牙周炎及其共病中的作用、克隆性造血发生的分子基础及临床意义等。先后在 Cell (2024,2022), Journal of Clinical Investigation 和Journal of Immunology等重要国际性学术期刊发表约20篇论文。其中以第一作者(包含同等贡献作者)的SCI论文12 篇,总影响因子大于239。
课题组未来的主要研究方向包括:1)免疫细胞在牙周炎发生中的作用机制;2)巨噬细胞胞葬(Efferocytosis)在牙周炎症消退及组织再生中的作用机理;3)
牙周炎及其共病的免疫学致病机制与治疗策略。针对“牙周炎及其共病机制”这一核心科学问题,深入探究和明确不同慢性炎症性疾病之间的关联机制,尤其是牙周炎、类风湿性关节炎、慢性阻塞性肺疾病(COPD)与社会压力之间的内在关联机制。在此基础之上,针对其中关键的分子,合成相应的多肽或者抗体类药物,研究其潜在的治疗效果,推动牙周炎及相应慢性炎症性疾病的治疗与康复。
代表性论文/著作
1)Hui Wang, Kimon Divaris, Bohu Pan, Xiaofei Li, Jong-Hyung Lim, Gundappa Saha, Marko Barovic, Danai Giannakou, Jonathan M Korostoff, Yu Bing, Souvik Sen, Kevin Moss, Di Wu, James D Beck, Christie M Ballantyne, Pradeep Natarajan, Kari E North, Mihai G Netea, Triantafyllos Chavakis, George Hajishengallis. Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss. Cell. 2024, 187(14):3690-3711.
Reported by Penn News: New insights on stem cell clones and inflammation in the bones | Penn Today (upenn.edu)
Reported by BioArt:https://www.booksci.cn/article/76252.htm
Highlighted by Cell Research: https://www.nature.com/articles/s41422-024-01006-2
2)Xiaofei Li, Hui Wang (co-first author), Xiang Yu, Gundappa Saha, Lydia Kalafati, Charalampos Ioannidis, Ioannis Mitroulis, Mihai G. Netea, Triantafyllos Chavakis, George Hajishengallis. Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. Cell, 2022, 185 (10), 1709-1727.
Reported by Penn News: https://penntoday.upenn.edu/news/how-one-inflammatory-disorder-exacerbates-another
Highlighted by Nature Reviews Immunology: https://www.nature.com/articles/s41577-022-00733-0
Highlighted by Nature Immunology: https://www.nature.com/articles/s41590-022-01234-x
Highlighted by Trends in Immunology: https://www.cell.com/trends/immunology/fulltext/S1471-4906(22)00091-6
3)Hui Wang, Hidetaka Ideguchi, Tetsuhiro Kajikawa, Dimitrios C. Mastellos, John D. Lambris, and George Hajishengallis. Complement is required for microbe-mriven induction of Th17 and periodontitis,The Journal of Immunology, 2022, 209 (7), 1370-1378.
4)Hui Wang, Xiaofei Li, Tetsuhiro Kajikawa, Jieun Shin, Jong-Hyung Lim, Ioannis Kourtzelis, Kosuke Nagai, Jonathan M Korostoff, Sylvia Grossklaus, Ronald Naumann, Triantafyllos Chavakis, George Hajishengallis. "Stromal cell-derived DEL-1 inhibits Tfh cell activation and inflammatory arthritis." The Journal of Clinical Investigation, 2021, 131(19).
Selected as Editor’s pick: https://www.jci.org/this-month/2021/11
Reported by Penn News: https://penntoday.upenn.edu/news/two-pronged-approach-keep-rheumatoid-arthritis-check
其他
实验室热忱欢迎有志于牙周免疫、克隆性造血和训练免疫研究的博士、硕士、本科生的加入。
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