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硕导

李雨庆

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姓名:李雨庆

职称:研究员

所在学系:口腔基础医学系

研究生导师类别:硕导

电子邮箱:liyuqing@scu.edu.cn

办公地址:四川省成都市人民南路三段14号华西口腔医院科研楼B604

研究方向包括:口腔微生物组与人体健康、口腔微生物致病的分子机制、微生物生物膜与感染、口腔菌斑性疾病防治新技术及口腔护理产品研发、抗菌及抗生物膜新药和新材料开发、口腔微生物在疾病检测及预警中的应用等。

个人简介:

微生物学博士,四川大学华西口腔医学院研究员、硕士生导师,四川省口腔医学会口腔生物学专委会委员,四川省微生物学会理事、秘书长,四川大学大学生创新创业训练计划指导教师。2011年毕业于华中农业大学生命科学技术学院农业微生物学国家重点实验室,获博士学位。美国福赛斯研究所(2014-2015)、法国巴斯德研究所(2017)以及美国哈佛医学院/波士顿儿童医院(2019)访问学者。

先后主持国家自然科学基金面上项目、青年基金等10余项课题。近5年以第一或通讯作者在J Dent Res、Environ Microbiol、J Mater Chem B、Antimicrob Agents Chemother、Int J Oral Sci等国内外学术期刊发表论文40余篇。获国家授权发明专利8项。主编教材专著3部,参编6部。参与获得省部级科技奖励一等奖1项,二等奖2项。J Oral Microbiol编委及多本学术期刊审稿专家。

主讲本科生及研究生的《口腔微生物学》、《口腔生物化学》及留学生的《Oral Microbiology》等课程。主持校级课程建设项目1项,发表教改论文2篇。获四川大学大学生课外科技实践活动优秀指导教师等荣誉。

研究领域:

龋病、牙周病、种植体周围疾病等都是常见多发的口腔菌斑性疾病,严重危害口腔及全身健康。

目前,我们综合利用微生物遗传学、微生态学、生物化学、蛋白质组、转录组、代谢组等手段,通过研究牙菌斑生物膜中关键微生物的致病机制,开发以关键微生物为作用靶点的菌斑防控及微生态调节技术,为口腔菌斑性疾病及相关全身疾病的预防和治疗提供新的策略。

论文/著作:发表论文(*为通讯作者):

1. Miao Lu, Zhenting Xiang, Tao Gong, Xuedong Zhou, Zhong Zhang, Boyu Tang, Jumei Zeng, Lingyun Wang, Tao Cui, Yuqing Li*. (2020) Intrinsic Fluoride Tolerance Regulated by a Transcription Factor. Journal of Dental Research. 99(11):1270-1278.

2. Shuang Jiang#, Jumei Zeng#, Xuedong Zhou, Yuqing Li*. (2018) Drug Resistance and Gene Transfer Mechanisms in Respiratory/Oral Bacteria. Journal of Dental Research. 97(10): 1092-1099.

3. Xin Zheng, Xingqun Cheng, Lin Wang, Wei Qiu, Suping Wang, Yuan Zhou, Mingyun Li, Yuqing Li, Lei Cheng, Jiyao Li, Xuedong Zhou, Xin Xu*. (2015) Combinatorial effects of arginine and fluoride on oral bacteria. Journal of Dental Research. 94(2):344-353.

4. Keke Zhang#, Suping Wang#, Xuedong Zhou, Hockin H. K. Xu, Michael D. Weir, Yang Ge, Mingyun Li, Shida Wang, Yuqing Li, Xin Xu, Liwei Zheng, Lei Cheng*. (2015) Effect of antibacterial dental adhesive on multispecies biofilms formation. Journal of Dental Research. 94(4):622-629.

5. Xin Zheng, Keke Zhang, Xuedong Zhou, Chengcheng Liu, Mingyun Li, Yuqing Li, Renke Wang, Yan Li, Jiyao Li, Wenyuan Shi, Xin Xu*. (2013) Involvement of gshAB in the interspecies competition within oral biofilm. Journal of Dental Research. 92(9):819-824.

6. Xingqun Cheng, Xin Zheng, Xuedong Zhou, Jumei Zeng, Zhi Ren, Xin Xu, Lei Cheng, Mingyun Li, Jiyao Li, Yuqing Li*. (2016) Regulation of oxidative response and extracellular polysaccharide synthesis by a diadenylate cyclase in Streptococcus mutans. Environmental Microbiology. 18(3):904-922.

7. Xin Xu#, Jinzhi He#, Jing Xue#, Yan Wang, Kun Li, Keke Zhang, Qiang Guo, Xianghong Liu, Yuan Zhou, Lei Cheng, Mingyun Li, Yuqing Li, Yan Li, Wenyuan Shi, Xuedong Zhou*. (2015) Oral cavity contains distinct niches with dynamic microbial communities. Environmental Microbiology. 17(3):699-710.

8. Zhi Ren#, Tao Cui#, Jumei Zeng, Lulu Chen, Wenling Zhang, Xin Xu, Lei Cheng, Mingyun Li, Jiyao Li, Xuedong Zhou, Yuqing Li*. (2016) Molecule targeting glucosyltransferase inhibits Streptococcus mutans biofilm formation and virulence. Antimicrobial Agents and Chemotherapy. 60(1):126-135.

9. Chao Zheng, Song Li, Zhongyue Luo, Rui Pi, Honghu Sun, Qingxia He, Ke Tang, Mei Luo, Yuqing Li, David Couvin, Nalin Rastogi, Qun Sun*. (2015) Mixed infections and rifampin heteroresistance among Mycobacterium tuberculosis clinical isolates. Journal of Clinical Microbiology. 53(7):2138-2147.

10. Yuqing Li, Jumei Zeng, Jianfang Shi, Mingchao Wang, Muding Rao, Chaolun Xue, Yanli Du, Zheng-Guo He*. (2010) A proteome-scale identification of novel antigenic proteins in M. tuberculosis toward diagnostic and vaccine development. Journal of Proteome Research. 9(9):4812-4822.

11. Yi Wang#, Tao Cui#, Cong Zhang, Min Yang, Yuanxia Huang, Weihui Li, Lei Zhang, Chunhui Gao, Yang He, Yuqing Li, Feng Huang, Jumei Zeng, Cheng Huang, Qiong Yang, Yuxi Tian, Chunchao Zhao, Huanchun Chen, Hua Zhang, Zheng-Guo He*. (2010) Global protein-protein interaction network in the human pathogen Mycobacterium tuberculosis H37Rv. Journal of Proteome Research. 9(12):6665-6677.

12. Manman Guo, Hui Feng, Jun Zhang, Wenqing Wang, Yi Wang, Yuqing Li, Chunhui Gao, Huanchun Chen, Ying Feng, Zheng-Guo He*. (2009) Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Research. 19(7):1301-1308.

13. Jingjing Niu#, Jia Guo#, Ruolin Ding, Xiaoling Li, Yuqing Li*, Dan Xiao*, Cuisong Zhou*. (2019) An electrospun fibrous platform for visualizing the critical pH point inducing tooth demineralization. Journal of Materials Chemistry B. 7:4292-4298.

14. Guanyin Zhu#, Boyao Lu#, Tianxu Zhang, Ting Zhang, Chaoliang Zhang, Yuqing Li*, Qiang Peng*. (2018) Antibiofilm effect of drug-free and cationic poly(D,L-lactide-co-glycolide) nanoparticles via nano-bacteria interactions. Nanomedicine (London). 13(10):1093-1106.

15. Lulu Chen#, Xin Li#, Xuedong Zhou, Jumei Zeng, Zhi Ren, Lei Lei, Di Kang, Keke Zhang, Jing Zou, Yuqing Li*. (2018) Inhibition of Enterococcus faecalis growth and biofilm formation by molecule targeting c-di-AMP synthetase activity. Journal of Endodontics. 44(9):1381-1388.

16. Guojian Zhang#, Miao Lu#, Rongmei Liu, Yuanyuan Tian, Viet Ha Vu, Yang Li, Bao Liu, Ariel Kushmaro, Yuqing Li*, Qun Sun*. (2020) Inhibition of Streptococcus mutans biofilm formation and virulence by Lactobacillus plantarum K41 isolated from traditional Sichuan pickles. Frontiers in Microbiology. 11:774.

17. Zongbo Li, Zhenting Xiang, Jumei Zeng, Yuqing Li*, Jiyao Li*. (2019) A GntR Family Transcription Factor in Streptococcus mutans Regulates Biofilm Formation and Expression of Multiple Sugar Transporter Genes. Frontiers in Microbiology. 9:3224.

18. Boyu Tang, Tao Gong, Yujia Cui, Lingyun Wang, Chao He, Miao Lu, Jiamin Chen, Meiling Jing, Anqi Zhang, Yuqing Li*. (2020) Characteristics of Oral Methicillin-Resistant Staphylococcus epidermidis Isolated from Dental Plaque. International Journal of Oral Science. 12:15.

19. Xian Peng, Xin Xu, Yuqing Li, Lei Cheng, Xuedong Zhou*, Biao Ren*. (2020) Transmission routes of 2019-nCoV and controls in dental practice. International Journal of Oral Science. 12:9.

20. Xian Peng, Xuedong Zhou, Xin Xu, Yuqing Li, Yan Li, Jiyao Li, Xiaoquan Su, Shi Huang, Jian Xu, Ga Liao*. (2018) The Oral Microbiome Bank of China. International Journal of Oral Science. 10(2):16.

21. Yuan Wei, Wei Qiu, Xuedong Zhou, Xin Zheng, Keke Zhang, Shida Wang, Yuqing Li, Lei Cheng, Jiyao Li, Xin Xu*, Mingyun Li*. (2016) Alanine racemase is essential for the growth and interspecies competitiveness of Streptococcus mutans. International Journal of Oral Science. 8:231-238.

22. Lulu Chen#, Zhi Ren#, Xuedong Zhou, Jumei Zeng, Jing Zou*, Yuqing Li*. (2016) Inhibition of Streptococcus mutans biofilm formation, extracellular polysaccharide production, and virulence by an oxazole derivative. Applied Microbiology and Biotechnology. 100(2):857-867.

23. Jumei Zeng, Yuqing Li, Shuguang Zhang, Zheng-Guo He*. (2012) A novel high-throughput B1H-ChIP method for efficiently screening specific regulator-target promoter interactions. Applied Microbiology and Biotechnology. 93(3):1257-1269.

24. Xi Chen#, Binyou Liao#, Lei Cheng, Xian Peng, Xin Xu, Yuqing Li, Tao Hu, Jiyao Li, Xuedong Zhou*, Biao Ren*. (2020) The microbial coinfection in COVID-19. Applied Microbiology and Biotechnology. doi: 10.1007/s00253-020-10814-6.

25. Zhong Zhang, Xiaoying Lyu, Qianda Xu, Chenghui Li, Miao Lu, Tao Gong, Boyu Tang, Liu Wang, Weicai Zeng*, Yuqing Li*. (2020) Utilization of the extract of Cedrus deodara (Roxb. ex D.Don) G. Don against the biofilm formation and the expression of virulence genes of cariogenic bacterium Streptococcus mutans. Journal of Ethnopharmacology. 257:112856.

26. Jumei Zeng#, Leng Wu#, Qiushi Chen, Lingyun Wang, Wei Qiu, Xin Zheng, Xiaoming Yin, Jie Liu, Yan Ren*, Yuqing Li*. (2020) Comprehensive profiling of protein lysine acetylation and its overlap with lysine succinylation in the Porphyromonas gingivalis fimbriated strain ATCC 33277. Molecular Oral Microbiology. doi: 10.1111/omi.12312.

27. Anqi Zhang#, Jiamin Chen#, Tao Gong, Miao Lu, Boyu Tang, Xuedong Zhou*, Yuqing Li*. (2020) Deletion of csn2 gene affects acid tolerance and exopolysaccharide synthesis in Streptococcus mutans. Molecular Oral Microbiology. doi: 10.1111/omi.12308.

28. Tao Gong, Jumei Zeng, Boyu Tang, Xuedong Zhou*, Yuqing Li*. (2020) CRISPR-Cas systems in oral microbiome: from immune defense to physiological regulation. Molecular Oral Microbiology. 35(2):41-48.

29. Yuqing Li, Biao Ren, Xian Peng, Tao Hu, Jiyao Li, Tao Gong, Boyu Tang, Xin Xu*, Xuedong Zhou*. (2020) Saliva is a non-negligible factor in the spread of COVID-19. Molecular Oral Microbiology. 35(4):141-145.

30. Zhenting Xiang, Zongbo Li, Zhi Ren, Jumei Zeng, Xian Peng, Yuqing Li*, Jiyao Li*. (2019) EzrA, a cell shape regulator contributing to biofilm formation and competitiveness in Streptococcus mutans. Molecular Oral Microbiology. 34(5):194-208.

31. Leng Wu#, Tao Gong#, Xuedong Zhou, Jumei Zeng, Ruijie Huang, Yafei Wu, Yuqing Li*. (2019) Global analysis of lysine succinylome in the periodontal pathogen Porphyromonas gingivalis. Molecular Oral Microbiology. 34(2):74-83.

32. Tao Gong#, Boyu Tang#, Xuedong Zhou, Jumei Zeng, Miao Lu, Xiaoxin Guo, Xian Peng, Lei Lei, Bo Gong*, Yuqing Li*. (2018) Genome editing in Streptococcus mutans through self-targeting CRISPR arrays. Molecular Oral Microbiology. 33(6):440-449.

33. Wei Qiu#, Xin Zheng#, Yuan Wei, Xuedong Zhou, Keke Zhang, Shida Wang, Lei Cheng, Yan Li, Biao Ren, Xin Xu, Yuqing Li, Mingyun Li*. (2016) D-alanine metabolism is essential for growth and biofilm formation of Streptococcus mutans. Molecular Oral Microbiology. 31(5):435-444.

34. Yuqing Li, Karthik Krishnan, Margaret J. Duncan*. (2018) Post-translational regulation of a Porphyromonas gingivalis regulator. Journal of Oral Microbiology. 10(1):1487743.

35. Zhi Ren, Lulu Chen, Jiyao Li*, Yuqing Li*. (2016) Inhibition of Streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activity. Journal of Oral Microbiology. 8:31095.

36. Yuqing Li, Jumei Zeng, Hua Zhang, Zheng-Guo He*. (2010) The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis. BMC Microbiology. 10:242.

37. Chengcheng Liu#, Yulong Niu#, Xuedong Zhou, Keke Zhang, Lei Cheng, Mingyun Li, Yuqing Li, Renke Wang, Yi Yang, Xin Xu*. (2013) Hyperosmotic response of Streptococcus mutans: from microscopic physiology to transcriptomic profile. BMC Microbiology. 13:275.

38. Yuqing Li, Jumei Zeng, Zheng-Guo He*. (2010) Characterization of a C-terminus of the Mycobacterium tuberculosis MtrA responsible for both DNA binding and interaction with its two-component partner protein, MtrB. Journal of Biochemistry. 148(5):549-556.

39. Yang Qiu#, Yuqi Wu#, Boyao Lu, Guanyin Zhu, Tao Gong, Rui Wang, Qiang Peng*, Yuqing Li*. (2020) Inhibition of Methicillin-Resistant Staphylococcus aureus (MRSA) biofilm by Cationic poly (D, L-lactide-co-glycolide) Nanoparticles. Biofouling. 36(2):159-168.

40. Yuqing Li, Zheng-Guo He*. (2012) The mycobacterial LysR-type regulator OxyS responds to oxidative stress and negatively regulates expression of the catalase-peroxidase gene. PLoS ONE. 7(1):e30186.

41. Zhong Zhang, Yiduo Liu, Miao Lu, Xiaoying Lyu, Tao Gong, Boyu Tang, Liu Wang, Jumei Zeng*, Yuqing Li*. (2020) Rhodiola rosea extract inhibits the biofilm formation and the expression of virulence genes of cariogenic oral pathogen Streptococcus mutans. Archives of Oral Biology. 116:104762.

42. Boyu Tang#, Tao Gong#, Xuedong Zhou, Miao Lu, Jumei Zeng, Xian Peng, Shida Wang, Yuqing Li*. (2019) Deletion of cas3 gene in Streptococcus mutans affects biofilm formation and increases fluoride sensitivity. Archives of Oral Biology. 99:190-197.

43. Jing Chen#, Tiancheng Li#, Xuedong Zhou, Lei Cheng, Yuanyuan Huo, Jing Zou, Yuqing Li*. (2017) Characterization of the clustered regularly interspaced short palindromic repeats sites in Streptococcus mutans isolated from early childhood caries patients. Archives of Oral Biology. 83:174-180.

44. Wei Qiu#, Biao Ren#, Huanqin Dai, Lixin Zhang, Qiong Zhang, Xuedong Zhou, Yuqing Li*. (2017) Clotrimazole and econazole inhibit Streptococcus mutans biofilm and virulence in vitro. Archives of Oral Biology. 73:113-120.

45. Xingqun Cheng#, Xin Xu#, Jing Chen, Xuedong Zhou, Lei Cheng, Mingyun Li, Jiyao Li, Renke Wang, Wenxiang Jia, Yuqing Li*. (2014) Effects of simulated microgravity on Streptococcus mutans physiology and biofilm structure. FEMS Microbiology Letters. 359(1):94-101.

46. Jumei Zeng#, Lei Zhang#, Yuqing Li, Yi Wang, Mingchao Wang, Xin Duan, Zheng-Guo He*. (2010) Over-producing soluble protein complex and validating protein-protein interaction through a new bacterial co-expression system. Protein Expression and Purification. 69(1):47-53.

47. Tao Gong#, Miao Lu#, Xuedong Zhou, Anqi Zhang, Boyu Tang, Jiamin Chen, Meiling Jing, Yuqing Li*. (2019) CRISPR-Cas Systems in Streptococci. Current Issues in Molecular Biology. 32:1-38.

48. Miao Lu#, Tao Gong#, Anqi Zhang, Boyu Tang, Jiamin Chen, Zhong Zhang, Yuqing Li*, Xuedong Zhou*. (2019) Mobile Genetic Elements in Streptococci. Current Issues in Molecular Biology. 32:123-166.

49. Lei Lei#, Li Long#, Xin Yang, Yang Qiu, Yanglin Zeng, Tao Hu, Shida Wang*, Yuqing Li*. (2019) The VicRK Two-Component System Regulates Streptococcus mutans Virulence. Current Issues in Molecular Biology. 32:167-200.

50. Zhenting Xiang, Zongbo Li, Jumei Zeng, Yuqing Li*, Jiyao Li*. (2019) Regulation of Cell Division in Streptococci: Comparing with the Model Rods. Current Issues in Molecular Biology. 32:259-326.

51. Yandi Chen, Yuqing Li*, Jing Zou*. (2019) Intrageneric and Intergeneric Interactions Developed by Oral Streptococci: Pivotal Role in the Pathogenesis of Oral Diseases. Current Issues in Molecular Biology. 32:377-434.

52. Wenling Zhang, Xiaohong Deng, Xuedong Zhou, Yuqing Hao, Yuqing Li*. (2018) Influence of Helicobacter pylori culture supernatant on the ecological balance of a dual-species oral biofilm. Journal of Applied Oral Science. 26:e20170113.

53. 康迪, 王晖, 周学东, 李雨庆*. (2015) 口腔微生物与早产关系的研究进展. 中华口腔医学杂志. 50(8):507-510.

54. 王晖, 康迪, 周学东, 李雨庆*. (2018) 微生态调节技术在感染性疾病预防中的应用. 华西口腔医学杂志. 36(5):564-567.

55. 康迪, 李雨庆, 周学东*. (2017) 变异链球菌低pH感应系统的构建. 华西口腔医学杂志. 35(3):239-244.

56. 陈泽文, 黎静, 李恺得, 邱传彬, 谯跃银, 薛晶, 李雨庆*. (2016) 不同pH值对变异链球菌ffh基因表达的影响. 华西口腔医学杂志. 34(1):23-26.

57. 陈婧, 程兴群, 徐欣, 周学东, 李雨庆*. (2016) 微重力环境下的航天口腔医学研究新进展. 华西口腔医学杂志. 34(1):91-95.

58. 邱伟, 程兴群, 周学东, 李雨庆*. (2015) 牙龈卟啉单胞菌 c-di-AMP 代谢相关基因的克隆及表达纯化. 华西口腔医学杂志. 33(6):607-612.

59. 杨锴毓, 李雨庆, 周学东*. (2014) 口腔幽门螺杆菌与胃幽门螺杆菌感染关系的研究进展. 华西口腔医学杂志. 32(3):314-318.

60. 杜芹, 王艳, 徐欣, 李雨庆, 李明云, 邹静, 周学东*. (2014) 双生子儿童口腔微生物群组结构分析. 华西口腔医学杂志. 32(2):182-185.

61. 张文玲, 周学东, 郝玉庆, 李雨庆*. (2015) microRNA: 一种潜在新型诊断结核病的生物标志物. 四川大学学报(自然科学版). 52(6):1399-1403.

62. 张琼, 王诗达, 周学东*, 程磊, 李雨庆, Dilani B. Senadheera, Dennis G. Cvitkovitch. (2013) VicK激酶活性对变异链球菌的生物学影响. 四川大学学报(医学版). 44(6):911-915.

63. 程兴群, 徐欣, 周学东, 李雨庆*. (2017) 环二腺嘌呤核苷酸信号系统及其在口腔细菌致病机制中的研究展望. 国际口腔医学杂志. 44(6):647-653.

64. 杜芹, 邹静, 李雨庆, 李明云, 周学东*. (2016) 健康儿童口腔微生物的定植. 国际口腔医学杂志. 43(1):57-61.

65. 霍媛媛, 韩轩, 李雨庆, 邹静*. (2018) 龋病相关微生物群落结构与功能的多组学研究进展. 口腔疾病防治. 26(3):195-199.

66. 韩轩, 霍媛媛, 张琼, 李雨庆, 邹静*. (2018) 低龄儿童龋致龋微生物相关生物标志物的研究进展. 口腔疾病防治. 26(6):391-395.

主编及参编教材专著:

1. Editor in Chief: Xuedong Zhou, Yuqing Li.《Atlas of Oral Microbiology: From Healthy Microflora to Disease》. Academic Press. Elsevier. 2015. 该书入选国务院新闻办和新闻出版总署共同发起的"中国图书对外推广计划", 并获得中国出版协会年度输出版优秀图书奖.

2. Editor in Chief: Yuqing Li, Xuedong Zhou.《Pathogenic Streptococci: From Genomics to Systems Biology and Control》. Caister Academic Press. 2019.

3. Xuelian Huang, Qiang Guo, Biao Ren, Yuqing Li, Xuedong Zhou. Chapter 9: Models in Caries Research. Editor in Chief: Xuedong Zhou.《Dental Caries: Principles and Management》. Springer. 2016.

4. 主编: 李雨庆.《口腔微生物学实验指导》. 四川大学出版社. 2016.

5. 周学东, 李雨庆. 第二章第四节: 口腔微生物. 主编: 樊明文, 周学东.《口腔科学》. 高等教育出版社. 2019.

6. 李雨庆, 何金枝, 徐欣, 程磊, 李明云, 周学东. 口腔微生态宏基因组学研究. 主编: 邓子新, 喻子牛.《微生物基因组学及合成生物学进展》. 科学出版社. 2014.

7. 张平, 李明云, 薛晶, 周京琳, 何金枝, 李燕, 李雨庆, 梁景平, 王智. 第十七章: 口腔微生态学的研究技术. 主编: 周学东, 施文元.《口腔微生态学》. 人民卫生出版社. 2013.

8. 李雨庆, 王毅, 何正国. 结核分枝杆菌的基因调控网络研究进展. 主编: 喻子牛, 邵宗泽, 孙明.《中国微生物基因组研究》. 科学出版社. 2012.

其他国家授权发明专利:

1. ZL201810043682.2. 李雨庆, 龚涛, 彭显, 王诗达, 周学东. 一种特异性靶向变异链球菌gtfB位点的CRISPR-B基因编辑方法及应用.

2. ZL201710333236.0. 李雨庆, 康迪, 王晖, 彭显, 王诗达, 周学东. 一种基于基因重组质粒的变异链球菌生物膜pH指示计及其应用.

3. ZL201510029955.4. 李雨庆, 任智, 陈卢璐, 李明云, 李继遥, 邹静. 一种喹喔啉亚胺类化合物作为变异链球菌生物膜抑制剂的制备方法及应用.

4. ZL201510029929.1. 李雨庆, 陈卢璐, 任智, 李明云, 李继遥, 邹静. 一种恶唑酮类化合物作为变异链球菌生物膜抑制剂的应用.

5. ZL201310611103.7. 李雨庆, 徐欣, 刘向红, 李明云, 郭强, 周学东. 一种细菌胞内谷胱甘肽含量的测定方法.

6. ZL201810707596.7. 孙群, 张国建, 李雨庆, 卢淼, 刘绒梅, 李洋. 一株抗龋病植物乳杆菌及其应用.

7. ZL201010231572.2. 何正国, 李雨庆. 结核分枝杆菌的抗原蛋白及应用.

8. ZL200910060952.1. 何正国, 李雨庆. 一种结核分枝杆菌基因表达文库的构建方法及应用.

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