姓名：任彪

职称：副教授

所在学系：口腔基础医学系

研究生导师类别：硕导

电子邮箱：renbiao@scu.edu.cn

办公地址：四川省成都市人民南路三段14号华西口腔医院医技楼B604

研究方向：口腔微生物资源、口腔微生态与疾病防治

教育背景：

2007~2012：中国科学院微生物研究所 生物化学与分子生物学 硕博连读

2003~2007：北京科技大学 生物技术 学士

工作经历：

2018至今：华西口腔医学院/口腔疾病研究国家重点实验室 副教授

2017~2018：哈佛医学院 Visiting Scientist

2016~2017：华西口腔医学院/口腔疾病研究国家重点实验室 副教授

2014~2016：华西口腔医学院/口腔疾病研究国家重点实验室 讲师

2012~2014：中国科学院微生物研究所 助理研究员

学术任职：

四川省口腔医学会口腔生物学专委会 副主任委员

获奖：

2017年四川省科技进步奖一等奖

研究领域承担课题：

先后主持自然科学基金面上项目等国家级、省部级及横向项目11项，包括：国自然面上项目《不同形态的白色念珠菌与口腔上皮细胞相互作用的机制研究》;国自然青年基金项目《白假丝酵母菌与变异链球菌在龋齿发生中相互作用的机制研究》;四川省科技计划应用基础研究重点项目《青蒿素逆转白色念珠菌耐药的机制研究》等。

主要研究领域：

1. 口腔真菌与细菌跨界相互作用

探究口腔最常见真菌白色念珠菌与常见口腔细菌，如链球菌、放线菌、葡萄球菌等，之间的跨界相互作用，揭示“真菌-细菌”协同致病机制，找寻对抗“真菌-细菌”混合感染的药物靶点。

2. 口腔念珠菌病发病机制

利用自主知识产权的口腔白色念珠菌临床菌株库及突变菌株库，研究白色念珠菌导致口腔黏膜感染的机制以及抗白色念珠菌黏膜感染的药物靶点。

3. 抗口腔感染性疾病的药物研发

针对真菌感染，“真菌-细菌”混合感染以及耐药微生物，利用自主知识产权的药物筛选模型，发现高效抗感染，尤其是抗耐药微生物感染的新型化学药物及中药，并阐明新的抗感染机制。

论文/著作：

发表SCI论文96篇，其中一作及通讯28篇。H-index为26，2篇 “ESI高被引论文”。核心期刊11篇，其中一作及通讯6篇;主/参编中英文学术专著/教材8部，获授权国家发明专利8项，申请6项。

SCI论文：

1. Xian Peng, Xin Xu, Yuqing Li, Lei Cheng, Xuedong Zhou*, Biao Ren*. Transmission routes of 2019-nCoV and controls in dental practice. International Journal of Oral Science. 2020;12(1):9. doi: 10.1038/s41368-020-0075-9. (ESI高被引)

2. Junzhuo Lu#, Lei Cheng#, Yuyao Huang, Yaling Jiang, Chun-Hung Chu, Xian Peng, Mingyun Li, Hockin H. K. Xu, Xuedong Zhou*, Biao Ren*. Resumptive Streptococcus mutans Persisters Induced From Dimethylaminododecyl Methacrylate Elevated the Cariogenic Virulence by Up-Regulating the Quorum-Sensing and VicRK Pathway Genes. Frontiers in Microbiology. 2020;10(3102). doi: 10.3389/fmicb.2019.03102.

3. Xi Chen#, Binyou Liao#, Lei Cheng, Xian Peng, Xin Xu, Yuqing Li, Tao Hu, Jiyao Li, Xuedong Zhou*, Biao Ren*. The microbial coinfection in COVID-19. Appl Microbiol Biotechnol. 2020;104(18):7777-7785. doi: 10.1007/s00253-020-10814-6.

4. Hui Chen, Yujie Zhou, Xuedong Zhou, Binyou Liao, H. H. Kun Xu, Chunhung Chu, Lei Cheng*, Biao Ren*. Dimethylaminododecyl methacrylate inhibits Candida albicans and oropharyngeal candidiasis in a pH-dependent manner. Appl Microbiol Biotechnol. 2020;104(8):3585-3595. doi: 10.1007/s00253-020-10496-0.

5. Hui Chen, Xuedong Zhou, Biao Ren*, Lei Cheng*. The regulation of hyphae growth in Candida albicans. Virulence. 2020;11(1):337-348. doi: 10.1080/21505594.2020.1748930.

6. Wei Qiu, Yujie Zhou, Zixin Li, Tu Huang, Yuhan Xiao, Lei Cheng, Xian Peng, Lixin Zhang*, Biao Ren*. Application of Antibiotics/Antimicrobial Agents on Dental Caries. BioMed Research International. 2020;2020:1-11. doi: 10.1155/2020/5658212.

7. Ming Liao#, Ting Tong#, Yawen Zong#, Xuedong Zhou, Lei Cheng, Ruijie Huang*, Biao Ren*, Gil Alterovitz. Application of Omics and Bioinformatics Tools in Streptococcus Research. Current issues in molecular biology. 2019;32:327-376. Epub 2019/06/06. doi: 10.21775/cimb.032.327.

8. Ling Deng#, Ling Zou#, Juan Wu, Haixia Liu, Tao Luo, Xuedong Zhou, Wei Li*, Biao Ren*. Voriconazole inhibits cross-kingdom interactions between Candida albicans and Actinomyces viscosus through the ergosterol pathway. Int J Antimicrob Agents. 2019;53(6):805-813. doi: 10.1016/j.ijantimicag.2019.02.010.

9. Ling Deng#, Wei Li#, Yuanli He, Juan Wu, Biao Ren*, Ling Zou*. Cross-kingdom interaction of Candida albicans and Actinomyces viscosus elevated cariogenic virulence. Archives of oral biology. 2019;100:106-112. doi: 10.1016/j.archoralbio.2019.02.008.

10. Yangyu Lu, Zhiyan Zhou, Longyu Mo, Qiang Guo, Xian Peng, Tao Hu, Xuedong Zhou, Biao Ren*, Xin Xu*. Fluphenazine antagonizes with fluconazole but synergizes with amphotericin B in the treatment of candidiasis. Applied Microbiology and Biotechnology. 2019;103(16):6701-6709. Epub 2019/06/16. doi: 10.1007/s00253-019-09960-3.

11. Yujie Zhou#, Hong Yang#, Xuedong Zhou, Hongke Luo, Fan Tang, Jin Yang, Gil Alterovitz, Lei Cheng*, Biao Ren*. Lovastatin synergizes with itraconazole against planktonic cells and biofilms of Candida albicans through the regulation on ergosterol biosynthesis pathway. Applied Microbiology and Biotechnology. 2018;102(12):5255-5264.

12. Yujie Zhou, Min Liao, Chengguang Zhu, Yao Hu, Ting Tong, Xian Peng, Mingyun Li, Mingye Feng, Lei Cheng, Biao Ren*, Xuedong Zhou*. ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection. International Journal of Oral Science. 2018;10:9.

13. Tianmu Wu, Bolei Li, Xuedong Zhou, Yao Hu, Huajin Zhang, Yingkang Huang, Hockin H.K. Xu, Qiang Guo, Mingyun Li, Mingye Feng, Xian Peng, Michael D Weir, Lei Cheng*, Biao Ren*. Evaluation of novel anti-caries adhesive via secondary caries animal model. Caries Res. 2018;52:14-21.

14. Yiyuan Xue, Qian Lu, Yuan Tian, Xuedong Zhou, Lei Cheng*, Biao Ren*. Effect of toothpaste containing arginine on dental plaque-a randomized controlled in situ study. J Dent. 2017;67:88-93.

15. Wei Qiu#, Biao Ren#, Huanqin Dai, Lixin Zhang, Qiong Zhang, Xuedong Zhou, Yuqing Li*. Clotrimazole and econazole inhibit Streptococcus mutans biofilm and virulence in vitro. Archives of oral biology. 2017;73:113-120.

16. Bolei Li, Xinxuan Zhou, Xuedong Zhou, Ping Wu, Mingyun Li, Mingye Feng, Xian Peng, Biao Ren*, Lei Cheng*. Effects of different substrates/growth media on microbial community of saliva-derived biofilm. FEMS Microbiology Letters. 2017;364(13):fnx123.

17. Yaling Jiang#, Wei Qiu#, Xuedong Zhou, Hao Li, Junzhuo Lu, Hockin HK Xu, Xian Peng, Mingyun Li, Mingye Feng, Lei Cheng*, Biao Ren*. Quaternary ammonium induced multi-drug tolerant Streptococcus mutans persisters elevate cariogenic virulence in vitro. International Journal of Oral Science. 2017;9:1-8.

18. Hui Chen, Qi Han, Xuedong Zhou, Keke Zhang, Suping Wang, Hockin HK Xu, Michael D Weir, Mingye Feng, Mingyun Li, Xian Peng, Biao Ren*, Lei Cheng*. Heat-polymerized resin containing dimethylaminododecyl methacrylate inhibits Candida albicans biofilm. Materials. 2017;10(4):431.

19. Xing Chen#, Biao Ren#, Ming Chen, Quanxin Wang, Lixin Zhang*, Guiying Yan*. NLLSS: predicting synergistic drug combinations based on semi-supervised learning. PLoS computational biology. 2016;12(7):e1004975. (ESI高被引)

20. Pei Huang#, Feng Xie#, Biao Ren#, Qian Wang, Jian Wang, Qi Wang, Wael M Abdel-Mageed, Miaomiao Liu, Jianying Han, Ayokunmi Oyeleye, Jinzhao Shen, Fuhang Song, Huanqin Dai, Xueting Liu*, Lixin Zhang*. Anti-MRSA and anti-TB metabolites from marine-derived Verrucosispora sp. MS100047. Applied Microbiology and Biotechnology. 2016;100(17):7437-7447.

21. Jinhui Cui#, Biao Ren#, Yaojun Tong, Huanqin Dai*, Lixin Zhang*. Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans. Virulence. 2015;6(4):362-371.

22. Biao Ren, Huan-Qin Dai, Gang Pei, Yao-Jun Tong, Ying Zhuo, Na Yang, Meng-Yi Su, Pei Huang, Yu-Zhuo Yang, Li-Xin Zhang*. ABC transporters coupled with the elevated ergosterol contents contribute to the azole resistance and amphotericin B susceptibility. Applied Microbiology and Biotechnology. 2014;98(6):2609-2616.

23. Hui Guo#, Biao Ren#, Huanqin Dai, Shengwang Dai, Yuhan Zhang, Yingmei Liu, Bin Cao, Lixin Zhang*. Reversal of meticillin resistance in Staphylococcus aureus by the anthelmintic avermectin. Int J Antimicrob Agents. 2014;44(3):274-276.

24. Xing Chen#, Biao Ren#, Ming Chen, Ming-Xi Liu, Wei Ren, Quan-Xin Wang, Li-Xin Zhang*, Gui-Ying Yan*. ASDCD: antifungal synergistic drug combination database. PLoS ONE. 2014;9(1):e86499.

25. Biao Ren, Na Yang, Jian Wang, Xiao-Long Ma, Qian Wang, Feng Xie, Hui Guo, Zhi-Heng Liu, Benoît Pugin, Li-Xin Zhang*. Amphibacillus marinus sp. nov., a member of the genus Amphibacillus isolated from marine mud. International Journal of Systematic and Evolutionary Microbiology. 2013;63(4):1485-1491.

26. Fuhang Song#, Biao Ren#, Ke Yu, Caixia Chen, Hui Guo, Na Yang, Hong Gao, Xueting Liu, Mei Liu, Yaojun Tong. Quinazolin-4-one coupled with pyrrolidin-2-iminium alkaloids from marine-derived fungus Penicillium aurantiogriseum. Marine drugs. 2012;10(6):1297-1306.

27. Xiangyang Liu#, Biao Ren#, Hong Gao, Mei Liu, Huanqin Dai, Fuhang Song, Zhenyan Yu, Shujin Wang, Jiangchun Hu, Chandrakant R Kokare, Lixin Zhang*. Optimization for the production of surfactin with a new synergistic antifungal activity. PLoS ONE. 2012;7(5):e34430.

28. Xiangyang Liu#, Biao Ren#, Ming Chen#, Haibin Wang, Chandrakant R Kokare, Xianlong Zhou, Jidong Wang, Huanqin Dai, Fuhang Song, Mei Liu, Jian Wang, Shujin Wang, Lixin Zhang. Production and characterization of a group of bioemulsifiers from the marine Bacillus velezensis strain H3. Applied Microbiology and Biotechnology. 2010;87(5):1881-1893.

中文核心期刊论文：

1. 廖敏, 程磊, 周学东, 任彪. 白色念珠菌对口腔黏膜疾病恶性转化作用的研究进展. 华西口腔医学杂志. 2020;4(38):431-437. doi: 10.7518/hxkq.2020.04.014.

2. 宗雅文, 程磊, 郭强, 周学东, 任彪. 中药酚性化合物对口腔微生物调节作用的研究进展. 华西口腔医学杂志. 2020;38(03):323-327.

3. 胡垚, 程磊, 郭强, 任彪. 白假丝酵母与口腔常见细菌相互作用的进展研究. 国际口腔医学杂志. 2019;6(46):663-669.

4. 王峥, 程磊, 周学东, 任彪. 放射性龋形成机制的研究进展. 口腔疾病防治. 2019;27(4):255-259. doi: 10.12016/j.issn.2096-1456.2019.04.010.

5. 陆君卓, 程磊, 周学东, 任彪. 持留菌的控制与清除研究进展. 医学研究生学报. 2018;31(1):77-82.

6. 李好, 程磊, 周学东, 任彪. 持留菌与抗药菌的相互关系及其转化. 中华微生物学与免疫学杂志. 2017;37(8):628-633. doi: 10. 3760/ cma. j.

其他长期担任Journal of Dental Research, Applied Microbiology and Biotechnology，International Journal of Oral Science，mSystems, Frontiers of Microbiology, Journal of Oral Microbiology, Archives of Oral Biology、Drug Delivery, Infection and Drug Resistance, International Journal of Nanomedicine, Materials Science & Engineering C, American Journal of Infection Control，Evidence-Based Complementary and Alternative Medicine，Drug Design Development and Therapy，华西口腔医学杂志、国际口腔医学杂志等杂志期刊审稿人。