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人才培养

博导

谢静

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姓名:谢静

职务:副教授

所在学系:口腔基础医学系

研究生导师类别:博导

电子邮箱:xiejing2012@scu.edu.cn

办公地址四川省成都市人民南路三段14号华西口腔医院科研楼704

研究方向:口腔基础医学,骨与关节病理

个人简介:

谢静,四川大学华西口腔医学院副教授,博士生导师。2012-2014年清华大学博士后,2014年入职华西口腔,2015-2016年美国阿拉巴马州立大学访问学者。中华医学会会员,中华口腔医学会口腔生物医学专委会委员,四川省口腔医学会口腔生物学专委会委员。基金方面,主持国家青年基金资助(项目批准号:81600840)和国家面上项目资助(项目批准号: 81771047)。科研方面,总共发表文章80篇,其中SCI 65篇,总共累计影响因子IF 超300,总引用次数超1500次,个人H-index = 19,发表五篇封面论文。第一和通讯的研究性论文被Nature Reviews Materials (IF, 71.189), Progress in Polymer Science (IF, 22.62), Cell Metabolism (21.567), 和Advanced Functional Materals (16.836)等高分杂志引用。人才培养方面,协助指导硕士研究生8人,博士研究生7人,其中硕士研究生3人获得国家一等奖学金,博士研究生3人获得国家一等奖学金。论文评审方面,申请人同时也作为 Advanced Science,Biomaterials, ACS Appl Mater & Inter, Cell Death Discovery, Expert Opinion On Therapeutic Targets, Cell Proliferation, International Journal of Biological Sciences, J TISSUE ENG REGEN M和Inflammation)等10多个SCI杂志的审稿人以及中文期刊《国际口腔医学杂志》、《中国组织工程研究》杂志的审稿人。

研究领域承担课题

1. 国家自然科学基金青年基金,项目批准号:81600840;

2. 国家自然科学基金面上项目,项目批准号:81771047。

主要研究领域

1. 细胞与其微环境的相互作用关系;

2. 骨与关节病理。

论文/著作

部分通讯作者和第一作者的论文(时间倒序)

1. Linyi Cai, Wenjing Liu, Yujia Cui, Yang Liu, Wei Du, Liwei Zheng, Caixia Pi, Demao Zhang, Jing Xie*, and Xuedong Zhou*. Biomaterial Stiffness Guides Cross-talk between Chondrocytes: Implications for a Novel Cellular Response in Cartilage Tissue Engineering. ACS Biomaterials Science & Engineering. 2020,6(8):4476-4489.

2. Wenjing Liu, Yujia Cui, Jieya Wei, Jianxun Sun, Liwei Zheng and Jing Xie*. Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress. International Journal of Oral Science. 2020,12(1):17.

3. Demao Zhang, Xin Li, Caixia Pi, Linyi Cai, Yang Liu, Wei Du, Wenbin Yang, Jing Xie*. Osteoporosis-decreased extracellular matrix stiffness impairs connexin 43-mediated gap junction intercellular communication in osteocytes. Acta Biochimica et Biophysica Sinica. 2020,52(5):517-526.

4. Chenchen Zhou, Demao Zhang, Wei Du, Jing Zou, Xiaobing Li, Jing Xie*. Substrate mechanics dictate cell-cell communication by gap junctions in stem cells from human apical papilla. Acta biomaterialia. 2020,107: 178-193.

5. Mingru Bai, Linyi Cai, Xin Li, Ling Ye, Jing Xie*. Stiffness and topography of biomaterials dictate cell‐matrix interaction in musculoskeletal cells at the bio-interface: A concise progress review. Journal of Biomedical Materials Research Part b-Applied Biomaterials. 2020,108(6):2426-2440.

6. Wenjing Liu, Demao Zhang, Xin Li, Liwei Zheng, Chen Cui, Yujia Cui, Jianxun Sun, Jing Xie* and Xuedong Zhou. TGF-β1 facilitates cell-cell communication in osteocytes via connexin43- and pannexin1- dependent gap junctions. Cell Death Discovery. 2019, 5:141.

7. Chenchen Zhou, Demao Zhang, Jing Zou, Xiaobing Li, Shujuan Zou, Jing Xie*. Substrate compliance directs the osteogenic lineages of stem cells from the human apical papilla via the processes of mechanosensing and mechanotransduction. ACS Applied Materials & Interfaces. 2019, 11(29):26448-26459.

8. Chenchen Zhou, Qingxuan Wang, Demao Zhang, Linyi Cai, Wei Du, Jing Xie*. Compliant substratum modulates vinculin expression in focal adhesion plaques in skeletal cells. International Journal of Oral Science (IF = 4.138). 2019, 11, 18.

9. QingxuanWang, Chenchen Zhou, Demao Zhang, Jing Zou, Wenjing Liu, Linyi Cai, Yujia Cui, Wenli Lai, Jing Xie*. The involvement of the ERK-MAPK pathway in TGF-β1–mediated connexin43-gap junction formation in chondrocytes. Connective Tissue Research (IF = 2.608). 2019, 60(5):477-486.

10. Qingxuan Wang, Chenchen Zhou, Xiaobing Li, Linyi Cai, Jing Zou, Demao Zhang, Jing Xie*, Wenli Lai. TGF-β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling. Cell proliferation. 2019,52(2): e12544.

11. Demao Zhang, Chenchen Zhou, Qingxuan Wang, Linyi Cai, Wei Du, Xiaobing Li, Xuedong Zhou, Jing Xie*. Extracellular Matrix Elasticity Regulates Osteocyte Gap Junction Elongation: Involvement of Paxillin in Intracellular Signal Transduction. Cellular physiology and biochemistry (IF=5.5) 2018;51:1013-1026.

12. Wenjing Liu, Yujia Cui, Jianxun Sun, Linyi Cai, Jing Xie*, Xuedong Zhou. Transforming growth factor-β1 up-regulates connexin43 expression in osteocytes via canonical Smad-dependent signaling pathway. Bioscience Reports (IF= 2.899). 2018;38(6). pii: BSR20181678.

13. Xiao-Yu Liu, Xin Li, Ming-Ru Bai, Xia Chen, Cheng-Lin Wang, Jing Xie*, Ling Ye. FGF-7 dictates osteocyte cell processes through beta-catenin transduction. Scientific Reports. 2018,8(1):14792.

14. Linyi Cai, Demao Zhang, Wenjing Liu, Yujia Cui, Junjun Jing, Jing Xie*, Xuedong Zhou. Effects of parathyroid hormone (1-34) on the regulation of the lysyl oxidase family in ovariectomized mice. RSC Advances. 2018,8, 30629-30641.

15. Demao Zhang, Junjun Jing, Feng Lou, Ruimin Li, Yilin Ping, FanyuanYu, Fanzi Wu, XiaoYang, Ruoshi Xu, Feifei Li, Ke Wang, Mingru Bai, Caixia Pi, Jing Xie*, Liwei Zheng, LingYe, Xuedong Zhou. Evidence for excessive osteoclast activation in SIRT6 null mice. Scientific Reports (IF= 4.122). 2018, 8(1):10992.

16. Linyi Cai, Xin Xiong, Xiangli Kong and Jing Xie*. The role of the lysyl oxidases in tissue repair and remodeling: a concise review. Tissue Engineering and Regenerative Medicine. 2017, 14: 15–30.

17. Linyi Cai, Shu An, Jinfeng Liao, Wenbin Yang, Xuedong Zhou, Jing Xie*. Influences of Tumor Necrosis Factor-α on Lysyl Oxidases and Matrix Metalloproteinases of Injured Anterior Cruciate Ligament and Medial Collateral Ligament Fibroblasts. Journal of Knee Surgery. 2017,30(1):78-87.

18. Ke Sun, Renhuan Huang, Songtao Wu, Zhaozhao Chen, Shuwen Deng, Jinglin Zhou, Jing Xie*. The Pleiotropic Effects of PPARs on Vascular Cells and Angiogenesis: Implications for Tissue Engineering. Current Stem Cell Research & Therapy. 2016, 11: 265-273.

19. Jing Xie, Demao Zhang, Ye ling, Quan Yuan, Zhou chenchen, Du Wei, Xuedong Zhou. Substrate elasticity regulates vascular endothelial growth factor A (VEGFA) expression in adipose-derived stromal cells: Implications for potential angiogenesis. Colloids and Surfaces B: Biointerfaces. 2019, 175: 576-585.

20. Jing Xie, Demao Zhang, Chenchen Zhou, Quan Yuan, Ling Ye, Xuedong Zhou. Substrate elasticity regulates adipose-derived stromal cell differentiation towards osteogenesis and adipogenesis through β-catenin transduction. Acta Biomaterialia, 2018,79:83-95.

21. Jing Xie, Chenchen Zhou, Demao Zhang, Linyi Cai, Wei Du, Xiaobing Li, Xuedong Zhou. Compliant Substratum Changes Osteocyte Functions: The Role of ITGB3/FAK/β-Catenin Signaling Matters. ACS Applied Bio Materials. 2018,1 (3):792–801.

22. Jing Xie, Demao Zhang, Yunfeng Lin, Quan Yuan, Xuedong Zhou. Anterior cruciate ligament transection - induced cellular and extracellular events in menisci: Implications for osteoarthritis. The American Journal of Sports Medicine. 2018;46(5):1185-1198.

23. Jing Xie, Chunli Wang, Wenbing Yang, Jue Wang, Cheng Chen, Liwei Zheng, KLP Sung, and Xuedong Zhou. Modulation of MMP-2 and MMP-9 through connected pathways and growth factors is critical for extracellular matrix balance of intra-articular ligaments. Journal of Tissue Engineering and Regenerative Medicine. 2018,12(1): e550–e565.

24. Jing Xie, Yanhua Hou, Yang Yao, Na Fu, Xiaoxiao Cai, Guo Li, Qiang Peng, Yunfeng Lin. Regulation of extracellular matrix remodeling proteins by osteoblasts in titanium nanoparticle-induced aseptic loosening model. Journal of Biomedical Nanotechnology (IF= 5.068), 2015, 11(10): 1826-1835.

25. Jing Xie, Na Fu, Lin-Yi Cai, Tao Gong, Guo Li, Qiang Peng and Xiao-Xiao Cai. The effects of interleukin-1β in modulating osteoclast-conditioned medium’s influence on gelatinases in chondrocytes through mitogen-activated protein kinases. International Journal of Oral Science (IF= 4.138), 2015, 7:220-231.

26. Jing Xie, Quanyou Zhang, Ting zhu, Yanyan Zhang, Bailin Liu, Jianwen Xu, Hucheng Zhao. Substrate stiffness-regulated matrix metalloproteinase output in myocardial cells and cardiac fibroblasts: Implications for myocardial fibrosis. Acta Biomaterialia, 2014, 10(1): 2463-2472.

27. Jing Xie, Jiahuan Jiang, Yanjun Zhang, ChunMing Xu, Lin Yin, Chunli Wang, Peter CY Chen, KL Paul Sung. TNF-α induced down-regulation of lysyl oxidase family in anterior cruciate ligament and medial collateral ligament fibroblasts. Knee, 2014, 21(1): 48-54.

28. Jing Xie, Chunli Wang, Dong-yue Huang, Yanyan Zhang, Jianwen Xu, Stanislav S Kolesnikovd, KL paul Sung, Hucheng Zhao. TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury. Journal of Biomechanics (IF= 2.431), 2013, 46(5): 890-898.

29. Jing Xie, Wei Huang, Jiahuan Jiang, Yan Xu, Chunming Xu, Li Yang, Peter CY Chen, KL Paul Sung. Differential expressions of lysyl oxidase family in ACL and MCL fibroblasts after mechanical injury. Injury (IF= 2.199), 2013, 44(7): 893-900.

30. Jing Xie, Chunli Wang, Lin Yin, ChunMing Xu, Yanjun Zhang, KL Paul Sung. Interleukin-1 beta influences on lysyl oxidases and matrix metalloproteinases profile of injured anterior cruciate ligament and medial collateral ligament fibroblasts. International Orthopaedics, 2013, 37(3): 495-505.

31. Jing Xie, Jiahuan Jiang, Yanjun Zhang, ChunMing Xu, Lin Yin, Chunli Wang, Peter CY Chen, KL Paul Sung. Up-regulation expressions of lysyl oxidase family in anterior cruciate ligament and medial collateral ligament fibroblasts induced by transforming growth factor-beta1. International Orthopaedics, 2012, 36(1): 207-213.

32. Jun Tang, Jing Xie(#), Wei Chen, Chenyi Tang, Jinjin Wu, Yiping Wang, XueDong Zhou, Hou-De Zhou, and Yi-Ping Li. Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation. Journal of Biological Chemistry. 2020, 295(33):11669-11681.

33. Shiyu Lin, Jing Xie(#), Tao gong, Sirong Shi, Tao Zhang, Na fu, Yunfeng Lin. Smad signal pathway regulates angiogenesis via endothelial cell in an adipose-derived stromal cell/endothelial cell co-culture, 3D gel model. Molecular and cellular biochemistry (IF = 2.561), 2016, 412(1-2):281-288.

34. Tao Zhang, Jing Xie(#), Ke Sun, Na Fu, Shuwen Deng, Shiyu Lin, Sirong Shi, Juan Zhong, and Yunfeng Lin. Physiological oxygen tension modulates the soluble growth factor profile after crosstalk between chondrocytes and osteoblasts. Cell Proliferation, 2016, 49(1):122-133.

35. Qiang Xie, Jing Xie(#),Juan Zhong, Xiangzhu Cun, Shiyu Lin, Yunfeng Lin, Xiaoxiao Cai. Hypoxia enhance angiogenesis in adipose-derived stromal cell/endothelial cell co-cultured 3D gel model. Cell Proliferation (IF=4.936), 2016, 49(2):236-345.

36. Sirong Shi, Jing Xie(#), Juan Zhong, Shiyu Lin, Zhang Tao, Sun ke, Na Fu, Xiaoru Shao and Yunfeng Lin. Effects of low oxygen tension on gene profile of soluble growth factors in co-cultured adipose-derived stromal cells and chondrocytes. Cell Proliferation, 2016, 49(3):341-351.

37. Tao gong, Jing Xie(#), Jinfeng Liao, Tao Zhang, shiyu lin, yunfeng lin. Nanomaterials and bone regeneration. Bone Research, 2015, 3:15029.

38. Na Fu, Jing Xie(#), Guo Li, Xiaoru Shao, Sirong Shi, Shiyu Lin, Shuwen Deng, Ke Sun, Yunfeng Lin. P34HB film promotes cell adhesion, in vitro proliferation, and in vivo cartilage repair. RSC Advances, 2015, 5(1): 21572-21579.

39. Xiangzhu Cun, Jing Xie(#), Shiyu Lin, Na Fu, Shuwen Deng, Qiang Xie, Juan Zhong, Yunfeng Lin. Gene profile of soluble growth factors involved in angiogenesis, in an adipose-derived stromal cell/endothelial cell co-culture, 3D gel model. Cell Proliferation (IF= 4.936), 2015, 48(4): 405-412.

40. Shiyu Lin, Jing Xie(#), Tao Gong, Sirong Shi, Tao Zhang, Na Fu, Ling Ye, Min Wang, Yunfeng Lin. TGFβ signalling pathway regulates angiogenesis by endothelial cells, in an adipose-derived stromal cell/endothelial cell co-culture 3D gel model. Cell Proliferation (IF= 4.936), 2015, 48(6):729-737.

41. Chunfeng Fu, Jing Xie(#), Ning Hu, Xi Liang, Rongfu Chen, Chunli Wang, Cheng Chen, Chunming Xu, Wei Huang, K-L Paul Sung. Titanium particles up-regulate the activity of matrix metalloproteinase-2 in human synovial cells. International Orthopaedics (IF=2.377), 2014, 38(5): 1091-1098.

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