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硕导

王琪

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姓名:王琪

职称:副教授

所在学系:口腔修复学系

研究生导师类别:硕导

电子邮箱:wqinno8751@foxmail.com

办公地址:四川省成都市人民南路三段14号华西口腔医院2楼D区

研究方向:牙周炎性疾病防治机理、口腔抗炎材料、口腔激光

个人简介:

2009年毕业于四川大学华西口腔医学院,获医学博士学位,毕业后于美国罗马琳达大学进行博士后学习,回国后留校任教。现任四川大学华西口腔医院修复学四级专家,国际牙科研究协会IADR会员;中华口腔医学会修复学会会员,中华口腔医学会口腔生物学会会员,四川省口腔医学院口腔生物学会会员。在Nature Index 收录期刊Journal of Biological Chemistry, 及Journal of periodontology, Journal of Controlled Release 等国际知名学术期刊发表论文50余篇,其中以第一作者/通讯作者发表论文30余篇,获授权国家发明专利2项,获得省级科技进步奖三等奖1项,成都市科技进步二等奖1项。

长期从事牙周/种植周炎症性疾病的分子机制及临床防治研究,从免疫和衰老角度,创新性建立以巨噬细胞为核心的牙周炎性衰老加重糖尿病牙周损伤理论模型,为口腔炎症性疾病的病因提出了新理论;从细胞分子机理和表观遗传角度,发现激活衰老相关分子网络成熟的分子机制,为该疾病前期预判贡献了新方法;从血糖感应角度,发明控释药物支架材料和具有三维响应结构的种植体及其制备方法,为临床治疗伴糖尿病牙周缺损研发了新材料。

研究领域:

1. 课题名称《上皮炎性衰老通过NLRC4/TLR5调控伴糖尿病牙周炎发生发展的研究》 类别:国家自然科学基金

2. 课题名称《增强PTPN2降低糖尿病性牙周炎炎症程度的分子机制研究》 类别:国家自然科学基金

3. 课题名称《血糖响应药物控释系统精准调控糖尿病性牙周炎的机理及应用研究》 类别:四川省科技计划国际合作项目

4. 课题名称《PTPN2负性调节JAK/STAT通路降低糖尿病牙周炎炎症程度的机制研究》 类别:四川省科技厅科技支撑计划

5. 课题名称《血糖响应药物控释材料的研发及其在口腔疾病治疗中的应用》 类别:成都市科技计划国际合作

论文/著作:

1. Qi Wang(*),Hao Li,Yu Xiao,Shuan Li,Bo Li,Xiaowen Zhao,Lin Ye,Bin Guo,Xinmin Chen,Yi Ding ,Chongyun Bao,Locally controlled delivery of TNFαantibody from a novel glucose-sensitive scaffold enhances alveolar bone healing in diabetic conditions,Journal of Controlled Release,2015,206(2015):232~242

2. Peng Zhang, Qian Wang, Lulingxiao Nie, Rui Zhu, Xinyi Zhou, Pengfei Zhao, Ning Ji, Xing Liang, Yi Ding, Quan Yuan, Qi Wang(*),Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation,Journal of Biology Chemistry,2019, 294(49):18807-18819

3. Qi Wang,Hao Li,Honghui Xie,Min Fu,Bin Guo,Yi Ding,Wei Li,Haiyang Yu(*),25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice,Journal of Steroid Biochemistry and Molecular Biology,2013,135:43-50

4. Lulingxiao Nie, Peng Zhang, Qian Wang, Xinyi Zhou, Qi Wang(*). LncRNA-triggered macrophage inflammaging deteriorates age-related diseases . Mediators of Inflammation . Mediators of Inflammation. 2019, 2019: 4260309

5. Xinyi Zhou, Qian Wang, Lulingxiao Nie, Peng Zhang, Pengfei Zhao, Quan Yuan, Ning Jia, Yi Ding, and Qi Wang(*),Metformin ameliorates the NLPP3 inflammasome mediated pyroptosis by inhibiting the expression of NEK7 in diabetic periodontitis,Archives of Oral Biology,2020,020AUG;116;104763

6. Qi Wang,Peng Zhang,Ray Aprecio,Dongjiao Zhang,Hao Li,Ning Ji,Omaima Mohamed,Wu Zhang,Yiming Li,Yi Ding(*),Comparison of Experimental Diabetic Periodontitis Induced by Porphyromonas gingivalis in Mice,J Diabetes Res,2016,2016:4840203~4840203

7. Xinyi Zhou, Peng Zhang, Qian Wang, Ning Ji, Sisi Xia, Yi Ding, and Qi Wang(*),Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7(Nek7) expression,Journal of Periodontology,2019,90(9):1032-1042

8. Qian Wang, Xinyi Zhou, Jingjing Jiang, Peng Zhang, Sisi Xia, Yi Ding, Qi Wang(*). Relationship between serum 25‐hydroxyvitamin D3 levels and severity of chronic periodontitis in type 2 diabetic patients: A cross‐sectional study . Journal of Periodontal Research . 2019,54(06):671–680

9. Peng Zhang , Wu Zhang, Dongjiao Zhang, Min Wang, Ray Aprecio, Ning Ji , Omaima Mohamed ,Yiming Li , Yi Ding , Qi Wang(*),25-Hydroxyvitamin D3-enhanced PTPN2 positively regulates periodontal inflammation through the JAK/STAT pathway in human oral keratinocytes and a mouse model of type 2 diabetes mellitus.Journal of Periodontal Research,2018; 53: 467-477

10. Wang, Q., Zhou, X., Zhang, P., Zhao, P., Nie, L., Ji, N., … Wang, Q*. (2020). 25-Hydroxyvitamin D3 positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice. Steroids, 2020,156:108570

11. Qi Wang(*),Wu Zhang,Hao Li,Raydolf Aprecio,Wan Wu,Yiqiao Lin,Yiming Li,Effects of 25-hydroxyvitamin D3 on cathelicidin production and antibacterial function of human oral keratinocytes,Cellular Immunology,2013,283(1-2):45~50

12. Hao Li(#),Qi Wang(#),Yu Xiao,Chongyun Bao,Wei Li(*),25-Hydroxyvitamin D-3-Loaded PLA Microspheres: In Vitro Characterization and Application in Diabetic Periodontitis Models,AAPS PharmSciTech,2013,14(2):880~889

13. Qi Wang,Congyun Bao,Clemens A. van Blitterswijk,Zhiqing Chen(*),Designing Biomaterials for maxillofacial and periodontal bone regeneration,Craniofacial Bone Research,2012,1(1)

14. Qi Wang,Jun Yang,Wu Zhang,Roxanne Khoie,Yiming Li,Jianguo Zhu,Zhiqing Chen,Manufacture and cytotoxicity of a lead-free piezoelectric ceramic as a bone substitute-consolidation of porous lithium sodium potassiumniobate by cold isostatic pressing,International Journal of Oral Science,2009,1(2):99~104

15. Qi Wang,Jinsong Liu,Jianguo Zhu,Yongmei Ye,Xiang Li,Zhiqing Chen,Piezoelectric and bonding properties of a cement-basedcomposite for dental application,Applies surface science,2008,225:574~576

16. Q Wang,Q Chen,J Zhu,C Huang,B. W. Darvell,Z. Chen,Effects of pore shape and porosity on the propertiesof porous LNKN ceramics as bone substitute,Mater Chem and Physic,2008,109:488~491

17. Q Wang,X Chen,J Zhu,B. W. Darvell,Z. Chen,Porous Li-Na-K niobate bone-substitute ceramics:Microstructure andpiezoelectric properties,Mater Letter,2008,62:3506~3508

18. Pengfei Zhao, Xiuxiu Song, Lulingxiao Nie, Qian Wang, Peng Zhang, Yi Ding, Qi Wang*. Efficacy of adjunctive photodynamic therapy and lasers in the non-surgical periodontal treatment: a Bayesian network meta-analysis [published online ahead of print, 2020 Aug 23]. Photodiagnosis Photodyn Ther. 2020;101969

19. Zhao, P., Wang, Q., Zhang, P., Zhou, X., Nie, L., Liang, X., Ding, Y., & Wang, Q*. (2020). Clinical efficacy of chlorhexidine as an adjunct to mechanical therapy of peri-implant disease: a systematic review and meta-analysis. The Journal of oral implantology, 10.1563/aaid-joi-D-19-00213. Advance online publication. https://doi.org/10.1563/aaid-joi-D-19-00213

20. Zhou Xinyi, Zhang Peng, Wang Qiang, Xia Sisi, Ji Ning, Wang Qi*. 25-Hydroxyvitamin D3 alleviates experimental periodontitis via promoting expression of cathelicidin in mice with type 2 diabetic mellitus. Journal of Nutritional Science and Vitaminology, 2018;64: 307-315

21. Hao Li,Qi Wang(*),Yi Ding,Congyun Bao,Wei Li,Mangiferin ameliorates Porphyromonas gingivalis-induced experimental periodontitis by inhibiting phosphorylation of nuclear factor-kappaB and Janus kinase 1-signal transducer and activator of transcription signaling pathways,J Periodontal Res,2017,52(1):1~7

22. Hao Li,Honghui Xie,Min Fu,Wei Li,Bin Guo,Yi Ding,Qi Wang(*),25-hydroxyvitamin D3 ameliorates periodontitis by modulating the expression of inflammation-associated factors in diabetic mice,Steroids,2013,78(2):115~120

23. Hao Li,Heng Yang,Yi Ding,Raydolf Aprecio,Wu Zhang,Qi Wang(*),Yiming Li,Experimental periodontitis induced by Porphyromonas gingivalis dose notalter the onset or severity of diabetes in mice,J Perio Res,2013,48(5):582~590

24. 王琪,周欣奕,丁一(*),炎性衰老在牙周炎中的作用,华西口腔医学杂志,2018,36(1):1-4

25. 赵鹏飞, 王琪,伴糖尿病种植骨缺损的病因及治疗研究进展 ,国际口腔医学杂志,2019, 46(02):126-130.

26. 张鹏,丁一,王琪(*),炎性衰老在糖尿病牙周炎中的作用机制及研究现状[J], 国际口腔医学杂志,2017(6):664-668

27. 李栓,王琪(*),IL4诱导巨噬细胞M2a亚型激活对糖尿病人口腔种植骨整合的影响,华西口腔医学杂志,2016,34

28. 李昊,肖宇,陈治清,王琪(*),李伟,25羟基维生素D3-聚乳酸微球的制备及其对骨髓间充质干细胞的作用,中华口腔医学杂志,2012,47(S1):239~243

29. 李昊,李伟,丁一,郭斌,谢红慧,付敏,王琪(*),非受体型蛋白酪氨酸磷酸酶2与核因子-kB在糖尿病牙周炎牙周组织破坏中的作用研究,华西口腔医学杂志,2012,30(6):598~602

30. 王倩; 张鹏; 周欣奕; 赵鹏飞; 聂鲁凌霄; 丁一; 王琪; 二甲双胍通过抑制炎性小体改善伴糖尿病牙周炎牙周组织炎症水平的研究,2019牙周病与植体周病新分类·新理论·新技术高峰论坛, 沈阳, 2019-7-20至2019-7-23

31. 参编专著《口腔生物力学》、《口腔修复学诊疗操作规程》、《基于病案的口腔医学生临床思维培训》

发明专利:

1. 王琪,李昊,叶林,赵晓文,肖宇,李波,邹雪,包崇云,李伟,陈新明,可用于牙周治疗的血糖感应控释药物的支架材料及其制备方法,2013.11.26,中国,专利号:2013106073567

2. 王琪,王倩,张鹏,周欣奕,赵鹏飞,聂鲁凌霄,梁星,丁一,具有成骨-抗炎-血糖三维响应结构的牙种植体及其制备方法,2020.06.23,中国,专利号:201911262423X

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