姓名：王琪

职称：教授

所在学系：口腔修复学系

研究生导师类别：博导

联系方式：qiwang8751@scu.edu.cn

研究领域：炎症衰老与口腔疾病、代谢紊乱与口腔疾病共病、口腔炎症性疾病与全身健康、数字技术与生物材料在口腔修复中的应用

个人简介

四川大学华西口腔医院教授，博士研究生导师，美国罗马琳达大学博士后，四川省学术技术带头人后备人选，四川省“卫生健康英才计划”中青年骨干人才，香港大学牙医学院荣誉教授，担任中华口腔医学会修复专委会委员，中华口腔医学会激光专委会委员，四川省口腔激光专委会副主任委员，四川省口腔生物材料专委会常务委员。长期从事口腔修复及牙周疾病的机制及防治相关基础和临床研究。主持国家自然科学基金及省部级基金 10 余项， 以第一/通讯作者在Signal Transduction and Targeted Therapy, Journal of Biology Chemistry, Journal of Dental Research, International Journal of Oral Science, Journal of Clinical Periodontology 等学术期刊发表学术论文 60 余篇，获国家发明专利授权 3 项。获四川省级科技进步奖三等奖 1 项，成都市科技进步二等奖 1 项。

代表性论文/著作

1.Dong H, Sun Y, Nie L, Cui A, Zhao P, Leung WK, Wang Q*. Metabolic memory: mechanisms and diseases. Signal Transduct Target Ther. 2024 Feb 28;9(1):38.

2.Nie L, Sun Y, Dong H, You M, Cui A, Yue Z, Zhao P, Lv Q, Ji N, Wang H, Xu X, Leung WK, Wang J, Wang Q*. DHFR-Driven Metabolic Memory Sustains Periodontal Tissue Destruction. J Dent Res. 2025 Jun 26:220345251340632. 

3.Yue Z, Nie L, Ji N, Sun Y, Zhu K, Zou H, Song X, Chen J, Wang Q*. Hyperglycaemia aggravates periodontal inflamm-aging by promoting SETDB1-mediated LINE-1 de-repression in macrophages. J Clin Periodontol. 2023 Dec;50(12):1685-1696.

4.Song X, Yue Z, Fan L, Zou H, Zhao P, Nie L, Zhu K, Jiang J, Lv Q, Wang Q*. Relationship between circulating senescence-associated secretory phenotype levels and severity of type 2 diabetes-associated periodontitis: A cross-sectional study. J Periodontol. 2023 Aug;94(8):986-996.

5.Wang Q, Nie L, Zhao P, Zhou X, Ding Y, Chen Q, Wang Q*. Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging. Int J Oral Sci. 2021 Mar 24;13(1):11.

6.Zhao P, Yue Z, Nie L, Zhao Z, Wang Q, Chen J, Wang Q*. Hyperglycaemia-associated macrophage pyroptosis accelerates periodontal inflamm-aging. J Clin Periodontol. 2021 Oct;48(10):1379-1392.

7.Zhang P, Wang Q, Nie L, Zhu R, Zhou X, Zhao P, Ji N, Liang X, Ding Y, Yuan Q, Wang Q*. Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation. J Biol Chem. 2019 Dec 6;294(49):18807-18819.

8.Qi Wang*, Hao Li, Yu Xiao, Shuan Li, Bo Li, Xiaowen Zhao, Lin Ye, Bin Guo, Xinmin Chen, Yi Ding, Chongyun Bao. Locally controlled delivery of TNFα antibody from a novel glucose sensitive scaffold enhances alveolar bone healing in diabetic conditions. Journal of Controlled Release, 2015, 206: 232~242.

其他