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硕导

陈文川

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姓名:陈文川

职称:教授

职务:锦江门诊部主任,锦江门诊部党支部书记

所在学系:口腔修复学系

研究生导师类别:硕导

电子邮箱:hxkqcwc@scu.edu.cn

办公地址:四川省成都市人民南路三段14号华西口腔医院二楼九诊室

研究方向:骨再生,种植体骨结合,低温等离子体的口腔应用

个人简介

教育背景

四川大学华西口腔医学院1998-2003口腔医学学士

四川大学华西口腔医学院2003-2006口腔医学硕士(口腔种植学)

四川大学华西口腔医学院2006-2009口腔医学博士(口腔修复学)

美国马里兰大学牙学院2010-2013博士后(生物医学工程)

工作经历

四川大学华西口腔医学院2009-2012讲师

四川大学华西口腔医学院2012-2018副教授

四川大学华西口腔医学院2018-今 教授

学术任职

四川省卫生健康委学术技术带头人后备人选

中华口腔医学会口腔修复学专业委员会青年委员

四川省口腔医学会口腔修复学专业委员会常委

四川省医学会口腔医学专业委员会青年委员

四川省医学会医学美学与美容专业委员会委员

个人荣誉

四川大学青年骨干教师(2013)

四川大学华西口腔医学院先进个人(2014)

口腔医学院青年教师教学基本功比赛二等奖(2015)

四川大学本科课堂教学质量优秀奖(2016)

四川大学华西口腔医学院先进个人(2017)

四川大学优秀实习指导教师(2018)

华夏医学科技奖三等奖(2018)

四川大学大学生创新创业与实践教育优秀指导教师(2020)

四川大学华西口腔医学院优秀共产党员(2020)

四川大学华西口腔医学院抗疫突出贡献个人(2020)

四川大学华西口腔医学院优秀创新创业指导教师(2020)

研究领域:

1. 低强度脉冲超声用于骨质疏松缺牙患者牙种植治疗的机理研究(国家自然科学基金青年基金项目81000455,1/2011-12/2013)

2. 低温等离子体在楔状缺损修复中的应用研究(成都市科技局科技惠民技术研发项目2015-HM01-00346-SF,8/2016-8/2018)

3. 低温等离子体刷用于治疗大鼠实验性牙周炎的作用探究(宁波纳新医疗科技有限公司18H0125,1/2018-12/2020)

4. Circ_HOMER1及其靶miRNAs调控人脐带间充质干细胞成骨分化的机制研究(国家自然科学面上项目81771049,1/2018-12/2021)

5. 种植体椅旁亲水活化技术(华西口腔医院临床研究项目LCYJ2019-13,1/2020-12/2022)

6. circCTTN调控人脐带间充质干细胞成骨分化的机制研究(四川省科学技术厅应用基础研究20YYJC1559,1/2020-12/2021)

7. 低温等离子种植体活化亲水仪促进种植体骨结合的作用研究(成都市科技局技术创新研发项目2019-YF05-01328-SN,1/2020-12/2020)

论文/著作:

1. Chen WC, Qing H, He Y, Wang J, Zhu ZM, Wang H. Gene expression patterns of osteocyte-like MLO-Y4 cells in response to cyclic compressive force stimulation. Cell Biol Int, 2010, 34(5): 425-32.

2. Chen WC, Ma YY, Ye H, He Y, Li X, Li JH, Zhu ZM, Wang H. ERK1/2 is involved in cyclic compressive force-induced IL-6 secretion in MLO-Y4 cells. BiochemBiophys Res Commun, 2010,401(3):339-43.

3. 周红波, 侯永福, 陈文川, 沈颉飞, 王剑, 朱智敏. 低强度脉冲超声促进钛种植体骨结合的实验研究. 中华口腔医学杂志. 2011. 46(7): 425-30.

4. Bao CY, Chen WC, Weir MD, Wahwah TH, Xu HHK. Effects of electrospun submicron fibers in calcium phosphate cement scaffold on mechanical properties and osteogenic differentiation of umbilical cord stem cells. Acta Biomater, 2011,7(11):4037-44.

5. Chen WC, Zhou HZ, Weir MD, Bao CY, Xu HHK. Umbilical cord stem cells released from alginate-fibrin microbeads inside macroporous and biofunctionalized calcium phosphate cement for bone regeneration. Acta Biomater, 2012,8(6):2297-2306.

6. Chen WC, Zhou HZ, Tang MH, Weir MD, Bao CY, Xu HHK. Gas-foaming calcium phosphate cement scaffold encapsulating human umbilical cord stem cells. Tissue Eng Part A, 2012,18(7-8):816-27.

7. Zhou HZ, Chen WC, Weir MD, Xu HHK. Biofunctionalized calcium phosphate cement to enhance the attachment and osteodifferentiation of stem cells released from fast-degradable alginate-fibrin microbeads. Tissue Eng Part A, 2012,18(15-16):1583-95.

8. Tang MH, Chen WC, Weir MD, Thein-Han W, Xu HHK. Human embryonic stem cell-encapsulation in alginate microbeads in macroporous calcium phosphate cement for bone tissue engineering. Acta Biomater. 2012,8(9):3436-45.

9. Chen WC, Zhou HZ, Weir MD, Tang MH, Bao CY, Xu HHK. Human embryonic stem cell-derived mesenchymal stem cell seeding on calcium phosphate cement-chitosan-RGD scaffold for bone repair. Tissue Eng Part A. 2013. 19(7-8): 915-27. (No. 1 in the “Top-Read Articles” list)

10. Song GD, Habibovic P, Bao CY, Hu J, van Blitterswijk CA, Yuan HP, Chen WC, Xu HHK. The homing of bone marrow MSCs to non-osseous sites for ectopic bone formation induced by osteoinductive calcium phosphate. Biomaterials, 2013,34(9):2167-76.

11. Liu J, Chen WC, Zhao ZH, Xu HHK. Reprogramming of mesenchymal stem cells derived from iPSCs seeded on biofunctionalized calcium phosphate scaffold for bone engineering. Biomaterials, 2013,34(32):7862-72.

12. Chen WC, Liu J, Manuchehrabadi N, Weir MD, Zhu ZM, Xu HHK. Umbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defects. Biomaterials, 2013,34(38):9917-25.

13. TheinHan WW, Liu J, Tang MH, Chen WC, Cheng LZ, Xu HHK. Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cell Seeding on Biofunctionalized Calcium Phosphate Cements. Bone Research. 2013,1(4): 371-84.

14. Liu X, Liao XJ, Luo E, Chen WC, Bao CY, Xu HHK. Mesenchymal stem cells systemically injected into femoral marrow of dogs home to mandibular defects to enhance new bone formation. Tissue Eng Part A. 2014,20(3-4): 883-92.

15. Liu X, Wang P, Chen WC, Weir MD, Bao CY, Xu HHK. Human embryonic stem cells and macroporous calcium phosphate construct for bone regeneration in cranial defects in rats. Acta Biomater2014;10:4484-93.

16. Tang MH, Chen WC (co-first author), Liu J, Weir MD, Cheng LZ, Xu HHK. Human induced pluripotent stem cell-derived MSC seeding on calcium phosphate scaffold for bone regeneration. Tissue Eng Part A. 2014,20(7-8): 1295-305.

17. Chen WC; Thein-Han WW, Weir MD; Chen QM; Xu HHK. Prevascularization of biofunctional calcium phosphate cement for dental and craniofacial repairs. Dental Materials. 2014,30(5): 535-44.

18. Wang P, Zhao L, Chen WC, Liu X, Weir MD, Xu HHK. Stem Cells and Calcium Phosphate Cement Scaffolds for Bone Regeneration. J Dent Res. 2014,93(7): 618-625.

19. Liu J, Chen WC, Zhao ZH, Xu HHK. Effect of NELL1 gene overexpression in iPSC-MSCs seeded on calcium phosphate cement. Acta Biomater. 2014,10(12): 5128-38.

20. Wang P, Liu X, Zhao L, Weir MD, Sun JY, Chen WC, Man Y, Xu HHK. Bone tissue engineering via human induced pluripotent, umbilical cord and bone marrow mesenchymal stem cells in rat cranium. Acta Biomater. 2015,18: 236-48.

20. Li L, Huang ZJ, Li L, Chen WC*, Zhu ZM*. Berberine in Combination with Insulin Has Additive Effects on Titanium Implants Osseointegration in Diabetes Mellitus Rats. Evid Based Complement Alternat Med, 2015,2015:824259. doi.org/10.1155/2015/824259.

21. Zhou HB, Hou YF, Zhu ZM, Xiao WX, Xu Q, Li L, Li X, Chen WC*. Effects of Low Intensity Pulsed Ultrasound on Implant Osseointegration in ovariectomized rats. J Ultrasound Med. 2016,35(4): 747-754.

22. Yang T, Xiao WX, Chen WC, Li L, Zhu ZM, Sui L. Effect of Carboxymethyl Chitosan and Aging Time on Synthesis and Storage of Amorphous Calcium Phosphate. J NanosciNanotechnol. 2016. 16(12): 12582-12589.

23. 周进茹, 陈西文, 李鑫, 李紫嫣, 朱智敏, 陈文川*. 美学教育在口腔修复研究生培养中的必要性探究. 国际口腔医学杂志. 2016. (03): 263-267.

24. 李鑫, 周进茹, 李紫嫣, 陈文川*. 第三代生物医用材料在口腔领域中的应用. 国际口腔医学杂志. 2016. (03): 309-313.

25. Xiao WX, Xu Q, Zhu ZM, Li L, Chen WC*. Different performances of CXCR4, integrin-1β and CCR-2 in bone marrow stromal cells (BMSCs) migration by low-intensity pulsed ultrasound stimulation. Biomed Tech (Berl). 2017. 62(1): 89-95.

26. Liu X, Chen WC, Zhang C, et al. Co-Seeding Human Endothelial Cells with Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells on Calcium Phosphate Scaffold Enhances Osteogenesis and Vascularization in Rats. Tissue Eng Part A. 2017. 23(11-12): 546-555.

27. Chen WC, Liu X, Chen QM, Bao CY, Zhao L, Zhu ZM, Xu HHK. Angiogenic and osteogenic regeneration in rats via calcium phosphate scaffold and endothelial cell coculture with hBMSCs, hUCMSCs, hiPSC-MSCs and hESC-MSCs. J Tissue Eng Regen Med. 2018. 12(1): 191-203.

28. 梁馨予, 石佳博, 陈文川, 朱智敏. 硅酸镁锂在骨组织工程中的研究进展. 国际口腔医学杂志. 2018. (03): 340-345.

29. Zhang YX, Xiong Y, Xie P, Ao XG, Zheng Z, Dong XQ, Li H, Yu QS, Zhu ZM, Chen M, Chen WC*. Non-thermal plasma reduces periodontitis-induced alveolar bone loss in rats. BiochemBiophys Res Commun. 2018. 503(3): 2040-2046.

30. Xiwen Chen, Wenchuan Chen*, Yun He, Yixin Zhang, Chenfeng Chen, Zhimin Zhu, Hang Wang. The p38 MAPK and NF-κB Pathways are Involved in Cyclic Compressive Force-induced IL-6 Secretion in MLO-Y4 Cells. Braz Arch Biol Technol. 2018, 61, e18170777.

31. 李鑫, 朱智敏, 李紫嫣, 周进茹,陈文川*. 前磨牙邻面板固位全瓷粘接桥修复的应用研究. 华西口腔医学杂志, 2019,37(03):285-289.

32. 谢鹏, 李鑫, 陈文川*. 炎性病变累及下颌神经管的病因及多学科治疗策略. 中国实用口腔科杂志. 2019,12(01):54-58.

33. 郑铮, 陈文川*. 生物学宽度概念在口腔种植中的结构、尺度及功能意义. 国际口腔医学杂志. 2019. 46(04): 481-487.

34. 周婧,陈文川*. 低温等离子体改善牙本质粘接的机制研究现状. 华西口腔医学杂志. 2019. 37(S): 294-297.

35. 谢宇婕,陈文川*. 牙颈部非龋性缺损粘接修复的影响因素. 华西口腔医学杂志. 2019. 37(S): 434-437.

36. Fan Y, Yu Q, Wang G, Tan J, Liu S, Pu S, Chen W, Xie P, Zhang Y, Zhang J, Liao Y, Luo A. Effects of Non-thermal Plasma Treatment on the Polysaccharide from Dendrobium nobileLindl. and Its Immune Activities in vitro. Int J Biol Macromol. doi: 10.1016/j.ijbiomac.2019.10.260.

37. 郑晓,陈文川. 环状RNA参与干细胞分化的研究进展及其组织工程应用展望. 生物医学工程学杂志. 2019. 36(6): 1038-1042.

38. Zheng Z, Ao XG, Xie P, Jiang F, Chen WC*. Proposal and In-depth Analysis of Emergency Treatment Procedures for Removing Fractured Abutments in Implants with Tapped-in Connections: Case Report. J Oral Implantol. 2020. 46(1): 51-56.

39. Tao Yang, Peng Xie, Zhenzhen Wu, Yunmao Lia, Wenchuan Chen, Zhichao Hao, Yushu Wang, Zhimin Zhu* and Wei Teng*. The Injectable Woven Bone-Like Hydrogel to Perform Alveolar Ridge Preservation With Adapted Remodeling Performance After Tooth Extraction. Front BioengBiotechnol. doi.org/10.3389/fbioe.2020.00119.

40. Zheng Zheng, XiaogangAo, Peng Xie, Jie Wu, Yuqing Dong, Deping Yu, Jian Wang, Zhimin Zhu, Hockin H. K. Xu, Chen WC*. Effects of novel non‐thermal atmospheric plasma treatment of titanium on physical and biological improvements and in vivo osseointegration in rats. Sci Rep. 2020, 10(1):10637.

41. Zheng Zheng, XiaogangAo, Peng Xie, Fan Jiang*, Chen WC*. The biological width around implant: A literature review. Journal of Prosthodontic Research. JPOR_2019_356_R1.

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