姓名：马其钊

职称：副研究员

所在学系：口腔正畸学系

研究生导师类别：硕导

联系方式：（邮箱）mqz2080@scu.edu.cn

研究领域：龋病相关微生物致病机制与微生态防治

个人简介

马其钊，副研究员，硕士研究生导师。主要从事儿童口腔常见疾病的诊疗、牙外伤序列治疗及儿童口腔健康管理等临床工作。研究聚焦龋病相关微生物致病机制与微生态防治，重点开展变异链球菌毒力调控、应激适应、蛋白质翻译后修饰及口腔微生物互作机制研究，并探索天然活性成分和微生态干预的防龋策略。主持国家级及省部级科研项目3项，以第一作者/通讯作者发表SCI收录论文20余篇，相关成果发表于PNAS、Genomics, Proteomics & Bioinformatics、PLOS Pathogens、mBio和International Journal of Oral Science等期刊。参与制定团体标准2项，现任四川省口腔医学会儿童口腔医学专业委员会青年委员。

代表性论文/著作

1.Qizhao Ma, Jing Li, Shuxing Yu, Jing Zhou, Yaqi Liu, Xinyue Wang, Dingwei Ye, Yumeng Wu, Tao Gong, Qiong Zhang, Lingyun Wang, Jing Zou, and Yuqing Li. YkuR functions as a protein deacetylase in Streptococcus mutans. Proceedings of the National Academy of Sciences. 2024;121(41):e2407820121. doi: 10.1073/pnas.2407820121.  

2. Qizhao Ma, Tao Hu, Yongwang Lin, Jing Li, Jun Huang, Qiong Zhang, Tao Gong, Xuedong Zhou, Lei Lei, Jing Zou, and Yuqing Li. Crosstalk between lysine lactylation and acetylation regulates lactate dehydrogenase in Streptococcus mutans. Genomics, Proteomics & Bioinformatics. 2025;23(6):qzaf073. doi: 10.1093/gpbjnl/qzaf073. 

3. Qizhao Ma, Jing Li, Shuxing Yu, Yaqi Liu, Jing Zhou, Xinyue Wang, Lingyun Wang, Jing Zou, and Yuqing Li. ActA-mediated PykF acetylation negatively regulates oxidative stress adaptability of Streptococcus mutans. mBio. 2024;15(10):e0183924. doi: 10.1128/mbio.01839-24.  

4. Jing Li#, Qizhao Ma#, Jun Huang, Yaqi Liu, Jing Zhou, Shuxing Yu, Qiong Zhang, Yongwang Lin, Lingyun Wang, Jing Zou, and Yuqing Li. Small RNA SmsR1 modulates acidogenicity and cariogenic virulence by affecting protein acetylation in Streptococcus mutans. PLOS Pathogens. 2024;20(4):e1012147. doi: 10.1371/journal.ppat.1012147.  

5. Qizhao Ma, Yangyang Pan, Yang Chen, Shuxing Yu, Jun Huang, Yaqi Liu, Tao Gong, Qiong Zhang, Qun Sun, Jing Zou, and Yuqing Li. Acetylation of lactate dehydrogenase negatively regulates the acidogenicity of Streptococcus mutans. mBio. 2022;13(5):e0201322. doi: 10.1128/mbio.02013-22.  

6. Yaqi Liu, Shuxing Yu, Xinyue Wang, Dingwei Ye, Munire Aili, Xiangqing Fu, Jing Zou*, and Qizhao Ma*. Integrated salivary microbiome and metabolome profiling reveals ecological and functional alterations in severe early childhood caries. Journal of Translational Medicine. 2026;24:53. doi: 10.1186/s12967-025-07541-9.  

其他