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博导

梁新华

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姓名:梁新华

职称:教授

职务:医务部部长,医务部党支部书记

所在学系:口腔颌面外科学系

研究生导师类别:博导

电子邮箱:lxh88866@scu.edu.cn

办公地址:四川省成都市人民南路三段14号华西口腔医院8楼外科门诊

研究方向:口腔颌面部肿瘤侵袭转移的防治;口腔颌面部肿瘤热疗的基础和临床研究;颞下颌关节疾病的防治

个人简介:

2001年,毕业于四川大学,获博士学位,并留校任职至今。先后2次分别前往美国著名的临床医学中心Mayo Clinic(1年)和美国国立卫生研究院(NIH),牙颅颌面研究中心的口咽癌研究所(NIDCR/OPCB)(1年半)研修。作为项目负责人,先后共获得7项国家自然科学基金,以第一作者或通讯作者身份在SCI期刊发表论文60余篇。目前是AACR active member、国际牙医师学院院士、唐立新名师奖获得者、四川省学术和技术带头人后备人选。研究成果先后获中华医学科技进步奖三等奖、四川省科学技术进步奖三等奖、教育部高等学校科学研究优秀成果奖科技进步二等奖、华夏医疗保健国际交流促进科技奖二等奖等。

研究领域:

1. 国家自然科学基金(面上项目):脂肪酸代谢相关信号通路PRRX1/PPARG2动态调控口腔鳞癌EMT和侵袭转移的分子机制 

2. 国家自然科学基金NSFC-NIH生物医学合作研究项目:髓源性细胞TGF-β信号通路调控HPV相关头颈鳞癌侵袭转移的分子机制

论文/著作:

1. Pang X, Wang SS, Zhang M, Jiang J, Fan HY, Wu JS, Wang HF, Liang XH, Tang YL. OSCC cell-secreted exosomal CMTM6 induced M2-like macrophages polarization via ERK1/2 signaling pathway. Cancer Immunol Immunother. 2021 Apr;70(4):1015-1029. (Liang XH 通讯作者)

2. Jiang YP, Tang YL, Wang SS, Wu JS, Zhang M, Pang X, Wu JB, Chen Y, Tang YJ, LiangXH. PRRX1-induced epithelial-to-mesenchymal transition in salivary adenoid cystic carcinoma activates the metabolic reprogramming of free fatty acids to promote invasion and metastasis. Cell Prolif. 2020 Jan;53(1):e12705(Liang XH 通讯作者)

3. Zhang WL, Liu Y, Jiang J, Tang YJ, Tang YL, Liang XH. Extracellular vesicle long non-coding RNA-mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles. Cancer Sci. 2020 Aug;111(8):2726-2735. (Liang XH 通讯作者)

4. Guoli Tian, Yuye Liang, Zihao Wei, Xuemei Qiu, Peiyang Yuan, Xin Zeng, Xinhua Liang, Lu Jiang, Qianming Chen. Successful treatment of milia en plaque on the lip using microwave thermotherapy. The Journal of Dermatology. 2020 Apr;47(4):e128-e129.(Xinhua Liang为通讯作者)

5. Wang SS, Zheng M, Pang X, Zhang M, Yu XH, Wu JB, Gao XL, Wu JS, Yang X, Tang YJ, Tang YL, Liang XH. Macrophage migration inhibitory factor promotes the invasion and metastasis of oral squamous cell carcinoma through matrix metalloprotein-2/9. Mol Carcinog, 2019, 58: 1809-1821.(Liang XH 通讯作者)

6. Zheng M, Cao MX, Luo XJ, Li L, Wang K, Wang SS, Wang HF, Tang YJ, Tang YL, Liang XH. EZH2 promotes invasion and tumour glycolysis by regulating STAT3 and FoxO1 signalling in human OSCC cells. J Cell Mol Med. 2019 ;23(10):6942-6954. (Liang XH 通讯作者)

7. Wang HF, Wang SS, Zheng M, Dai LL, Wang K, Gao XL, Cao MX, Yu XH, Pang X, Zhang M, Wu JB, Wu JS, Yang X, Tang YJ, Chen Y, Tang YL, Liang XH. Hypoxia promotes vasculogenic mimicry formation by vascular endothelial growth factor A mediating epithelial-mesenchymal transition in salivary adenoid cystic carcinoma. Cell Prolif. 2019 Apr 3:e12600. (Liang XH 通讯作者)

8. Fan HY, Yu XH, Wang K, Yin YJ, Tang YJ, Tang YL, Liang XH. Graphene quantum dots (GQDs)-based nanomaterials for improving photodynamic therapy in cancer treatment. Eur J Med Chem. 2019;182:111620. (Liang XH 通讯作者)

9. Feng H, Wang S, Liu Y, Liao X, Tang Y, Liang X. Microwave Ablation: A Novel Treatment for the Mucoceles of Anterior Lingual Salivary Glands. J Oral Maxillofac Surg. 2017;75(3):530-535. (Liang X 通讯作者)

10. Zhu GQ, Tang YL, Li L, Zheng M, Jiang J, Li XY, Chen SX, Liang XH. HIF-1α and HIF-2α play distinct and functionally overlapping roles in oral squamous cell carcinoma. Clinical Cancer Research, 2010,16(19):4732-4741(Liang XH 通讯作者)

11. Liang XH, He YW, Tang YL, Wu JL, Cao XP, Xiao GZ, Mao ZY. Thermochemotherapy of lower lip squamous cell carcinoma without metastases: an experience of 31 cases. J Craniomaxillofac Surg, 2010;38(4):260-5.(Liang XH 通讯作者)

12. Zhou H, Tang Y, Liang X, Yang X, Yang J, Zhu G, Zheng M, Zhang C. RNAi targeting urokinase-type plasminogen activator receptor inhibits metastasis and progression of oral squamous cell carcinoma in vivo. Int J Cancer,2009 ,125(2):453-462. (Liang X 通讯作者)

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