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博导

沈颉飞

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姓名:沈颉飞

职称:教授

职务:党委副书记兼纪委书记

所在学系:口腔修复学系

研究生导师类别:博导

电子邮箱:shenjiefei@scu.edu.cn

办公地址:四川省成都市人民南路三段14号华西口腔医院7楼B701

研究方向:口腔修复学

备用电子邮箱:jiefei.shen@qq.com(重要邮件建议同时发送2个邮箱)

个人简介:

毕业于四川大学华西口腔医学院,获博士学位。现任四川大学华西口腔医学院(华西口腔医院)教授,主任医师,博士生导师,院党委副书记兼纪委书记。日本齿科大学访问学者,国际牙医师学院(ICD)Fellow,英国格拉斯哥皇家内外科学院(RCPSG)Fellow;四川省学术技术带头人后备人选、四川省卫生健康委学术技术带头人。担任国际牙科研究协会(IADR)会员发展委员会委员;中华口腔医学会口腔修复专委会常委、口腔医学设备器材分会副主任委员;四川省口腔医学会理事、四川省医学会口腔医学专委会委员、四川省口腔修复专委会副主任委员。作为负责人承担国家科技支撑计划项目课题、国家自然科学基金等国家和省部级科研项目10项,发表论文60余篇,主参编专著5部。

研究领域:

主要从事口腔修复种植的基础和临床领域及交叉学科研究,包括口腔颌面部感觉功能的调控,如种植神经损伤后口颌面感觉功能异常、神经病理性疼痛的机制等,以及数字化口腔修复种植技术,如口腔数字化诊疗技术、种植修复中的数字化设计和3D打印等。

近年作为负责人承担的国家及省部级科研项目

1. 《胶质细胞Kir4.1调控神经损伤后口腔颌面部感觉功能异常的研究》国家自然科学基金面上项目

2. 《种植神经损伤中谷氨酸介导的三叉神经节神经元-卫星胶质细胞交互对话机制研究》国家自然科学基金面上项目

3. 《数字口腔诊疗规范及知识服务应用系统研发及示范》国家科技支撑计划项目课题

4. 《口腔颌面部神经损伤中Kir4.1介导的三叉神经节神经元-卫星胶质细胞交互对话机制研究》四川省科技厅应用基础研究计划重点项目

5. 《三叉神经节神经元交叉兴奋在口颌系统疼痛异常中的作用研究》四川省科技厅应用基础研究计划项目

6. 《以离子通道机械敏感性为基础的种植体骨感知机制及干预研究》成都市科技惠民项目

论文/著作:

近年发表主要学术论文

1. Jiu Lin, Yan-yan Zhang, Fei Liu, Xin-yi Fang, Meng-ke Liu, Chao-lan Huang, Hang Wang, Da-qing Liao, Cheng Zhou, Jie-Fei Shen*. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochemistry International. 2019 Oct 3;131:104567. doi: 10.1016/j.neuint.2019.104567. [Epub ahead of print]

2. Fei Liu, Yan-yan Zhang, Ning Song, Jiu Lin, Meng-ke Liu, Chao-Lan Huang, Cheng Zhou, Hang Wang, Min Wang, Jie-Fei Shen*. GABA(B) receptor activation attenuates inflammatory orofacial pain by modulating interleukin-1β in satellite glial cells: role of NF-κB and MAPK signaling pathways. Brain Research Bulletin 149 (2019) 240–250.

3. Lin Jiu; Liu Fei; Zhang Yan-yan; Song Ning; Liu Meng-ke; Fang Xin-yi; Liao Da-qing; Zhou Cheng; Wang Hang; Shen Jie-fei*;, P2Y14 receptor is functionally expressed in satellite glial cells and mediates interleukin-βand chemokine CCL2 secretion, Journal of Cellullar Physiology, 2019, 234: 21199-21210.

4. Yanyan Zhang, Ning Song, Fei Liu1, Jiu Lin, Mengke Liu, Chaolan Huang, Daqing Liao, Cheng Zhou, Hang Wang, Jiefei Shen*. Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain. International Journal of Oral Science. 2019,11(3):24.

5. N, Song, Liao DQ, Liu F, Zhang YY, Lin J, Wang H, and Shen JF*. Effect of Titanium Particles on the Voltage-Gated Potassium Channel Currents in Trigeminal Root Ganglion Neurons. Implant dentistry,2019,28: 54-61.

6. X, Wu, Ma Y, Chen H, Hao Z, Su N, Li X, Shen J*, and Wang H*. Lysophosphatidic Acid Induces Interleukin-6 and Cxcl15 Secretion from Mlo-Y4 Cells through Activation of the Lpa Receptor and Pkcθ Signaling Pathway. International immunopharmacology,2019,74: 105664.

7. X, Wu, Ma Y, Su N, Shen J, Zhang H, and Wang H*.Lysophosphatidic Acid: Its Role in Bone Cell Biology and Potential for Use in Bone Regeneration. Prostaglandins & other lipid mediators,2019,143: 106335.

8. N, Su, Liu Y, Yang X, Shen J, and Wang H*. Association of Malocclusion, Self-Reported Bruxism and Chewing-Side Preference with Oral Health-Related Quality of Life in Patients with Temporomandibular Joint Osteoarthritis. International dental journal,2018,68: 97-104.

9. Z, Hao, Ma Y, Liu W, Meng Y, Nakamura K, Shen J, and Wang H*. Influence of Low-Temperature Degradation on the Wear Characteristics of Zirconia against Polymer-Infiltrated Ceramic-Network Material. The Journal of Prosthetic Dentistry,2018, 120: 596-602.

10. Hao, Zhichao; Ma, Yuanyuan;Wu,Jun;Li,Xianxian;Chen,Helin;Shen,Jiefei*;Wang,Hang*,Osteocytes regulate osteoblast differentiation and osteoclast activity through Interleukin-6 under mechanical loading. RSC Advances, 2017, 7(79):50200~50209

11. Yu, Ke; Ma, Yuanyuan;Li,Xianxian;Wu,Xiangnan;Liu,Wenjia;Li,Xiaoyu;Shen,Jiefei*;Wang,Hang*,Lipopolysaccharide increases IL-6 secretion via activation of the ERK1/2 signaling pathway to up-regulate RANKL gene expression in MLO-Y4 cells,Cell Biology International,2017.1,41(1):84~92

12. H, Chen, Fu T, Ma Y, Wu X, Li X, Li X, Shen J, and Wang H*. Intermittent Administration of Parathyroid Hormone Ameliorated Alveolar Bone Loss in Experimental Periodontitis in Streptozotocin-Induced Diabetic Rats. Archives of oral biology,2017,83: 76-84.

13. H, Chen, Liu W, Wu X, Gou M, Shen J, and Wang H*. Advanced Glycation End Products Induced Il-6 and Vegf-a Production and Apoptosis in Osteocyte-Like Mlo-Y4 Cells by Activating Rage and Erk1/2, P38 and Stat3 Signalling Pathways. International immunopharmacology, 2017, 52: 143-49.

14. N, Su, Liao Y, Zhang H, Yue L, Lu X, Shen J, and Wang H*. Effects of Core-to-Dentin Thickness Ratio on the Biaxial Flexural Strength, Reliability, and Fracture Mode of Bilayered Materials of Zirconia Core (Y-Tzp) and Veneer Indirect Composite Resins. The Journal of prosthetic dentistry,2017,117: 150-57.

15. Liu, Fei ;Lu, Xiao-Wen ;Zhang, Yu-Jiao ;Kou, Liang ;Song, Ning ;Wu, Min-Ke ;Wang, Min ;Wang, Hang ;Shen, Jie-Fei*;, Effects of chlorogenic acid on voltage-gated potassium channels of trigeminal ganglion neurons in an inflammatory environment, Brain Research Bulletin, 2016,127:119-125.

16. Wu MK, Song N, Liu F, Kou L, Lu XW, Wang M, Wang H*, Shen JF*. Corrosion behaviours of the dental magnetic keeper complexes made by different alloys and methods. Int J Oral Sci. 2016,8(3):155-63.

17. Su N, Li C, Wang H*, Shen JF*, Liu W, Kou L. Efficacy and safety of articaine versus lidocaine for irreversible pulpitis treatment: A systematic review and meta-analysis of randomised controlled trials. Aust Endod J. 2016 Apr;42(1):4-15.

18. Su N, Liu Y, Yang X, Shen J, Wang H. Correlation between oral health-related quality of life and clinical dysfunction index in patients with temporomandibular joint osteoarthritis. J Oral Sci. 2016;58(4):483-490.

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