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硕导

程然

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姓名:程然

职称:副教授

所在学系:口腔内科学系

研究生导师类别:硕导

电子邮箱:chengran@scu.edu.cn

办公地址:四川省成都市人民南路三段14号华西口腔医院5楼A区

研究方向:口腔感染性疾病的病因防治

个人简介:

2009毕业于四川大学华西口腔医学院,在美国Cedars Sinai医学中心访问学习一年。现任四川省医学会口腔预防专委会常务委员、中华医学会口腔预防专业委员会委员。临床工作以牙体牙髓疾病及其儿童口腔疾病为主要方向。科研方向为口腔感染性疾病中细胞微生物相互作用机制及防治研究,参与编写《实用牙体牙髓病治疗学》、《口腔力学生物学》等专著,参与获得四川省科技进步奖二等奖,承担及参加国家自然科学基金、省、部级基金十余项,负责校级教改项目两项,发表SCI论文20余篇,发表SSCI和SCI收录教改论文各一篇。

研究领域

1. 国家自然科学基金,81970948,Caspase-4/-5/-11非经典炎性体通路引发高水平焦亡在牙周炎中的作用及机制研究,2020/1-2023/12,55万,进行中,主持

2. 四川省科技厅重点研发项目,2020YFS0178,焦亡相关Caspase及其影响的锌指蛋白A20在预警牙龈炎-牙周炎转归中的作用研究,2020/1-2021/12,20万,主持

3. 四川省国际合作项目,2015HH0035,间充质干细胞向牙髓归巢及失巢凋亡机制研究,2015/01-2017/12,20万元,主持

4. 国家自然科学基金青年项目,1000429,Wnt/β-catenin新交互通路在牙髓细胞早期修复的作用及分子机制研究,2011/01-2013/12、20万元,已结题,主持

论文/著作

1. Cheng R, Billet S, Liu C, et al. Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. Oncogene. 2020;39(7):1543-1556.

2. Mingming Li, Zhiwu Wu, Rui Zhang, Lei Lei, Siqi Ye, Ran Cheng,Tao Hu. Comparison of oral health behaviour between dental and non-dental undergraduates in a university in southwestern China——exploring the future priority for oral health education. BMC Oral Health 20, 249 (2020).

3. Cheng R, Wu Z, Li M, Shao M, Hu T. Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review. Int J Oral Sci. 2020;12(1):2.

4. Zhang R, Zhang B, Li M, He J, Hu T, Cheng R. Application of a three-session-procedure based on experiential learning in a tooth brushing course for Chinese dental students. BMC Med Educ. 2019;19(1):44.

5. Ran Cheng; Yuchao Feng; Rui Zhang; Wen Liu; Lei Lei; Tao Hu* ,The extent of pyroptosis varies in different stages of apical periodontitis., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018, 1864(1):226~237.

6. Ran Cheng; Wen Liu; Rui Zhang; Yuchao Feng; Neil A Bhowmick*; Tao Hu*, Porphyromonas gingivalis-Derived Lipopolysaccharide Combines Hypoxia to Induce Caspase-1 Activation in Periodontitis, Frontiers in Cellular and Infection Microbiology, 2017, 7: 474.

7. Li Cheng; Jue Xu; Yuyan Qian; Hongying Pan; Hui Yang; Meiying Shao*, Tao Hu, Ran Cheng*. Interaction between mDia1 and ROCK in Rho-induced migration and adhesion of human dental pulp cells, International Endodontic Journal, 2017, 50(1): 15~23.

8. Yuyan Qian; Meiying Shao; Wenlin Zou; Linyan Wang; Ran Cheng*; Tao Hu, Focal adhesion kinase maintains, but not increases the adhesion of dental pulp cells, Human Cell, 2017, 30(2): 98~105.

6. Cheng R, Li D, Shi X, Gao Q, Wei C, Li X, Li Y, Zhou H*. Reduced CX3CL1 Secretion Contributes to the Susceptibility of Oral Leukoplakia-Associated Fibroblasts to Candida albicans. Frontiers in Cellular and Infection Microbiology.2016,6: 150.

10. Cheng R, Hu T*, Bhowmick NA*.Be resistant to apoptosis: a host factor from gingival fibroblasts. Cell Death & Disease.2015,6:e2009-e2009.

11. Ran Cheng, Diptman Choudhury, Chuanxia Liu, Sandrine Billet, Tao Hu*, Neil A Bhowmick*.Gingival fibroblasts resist apoptosis in response to oxidative stress in a model of periodontal diseases. Cell Death Discovery.2015,1:15046.