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博导

江潞

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姓名:江潞

职称:教授

职务:研究生部部长/口腔黏膜病科副主任/口腔黏膜病科党支部书记

所在学系:口腔内科学系

研究生导师类别:博导

电子邮箱:jianglu@scu.edu.cn

办公地址:四川省成都市人民南路三段14号华西口腔医院5楼D区口腔黏膜病科

研究方向:口腔黏膜病的病因及防治

个人简介:

2008年在四川大学华西口腔医学院获口腔临床医学博士学位,之后留校任教。2009-2011年先后在美国加州大学洛杉矶分校(UCLA)和伊利诺伊州立大学芝加哥分校(UIC)口腔医学院进行博士后研究。中华口腔医学会口腔黏膜病专业委员会委员,四川省口腔医学会口腔黏膜病专业委员会副主任委员,《华西口腔医学》杂志常务编委。国际牙医学院(ICD)Fellow,入选教育部 “新世纪优秀人才支持计划”,霍英东基金获得者,四川省杰出青年科技人才,四川省第十二批省卫生计生委学术技术带头人后备人选,2009年四川省优秀博士论文获得者。主攻口腔黏膜病的病因与防治,在“口腔黏膜潜在恶性疾患恶变过程中的多分子事件及其临床意义”等方面取得创新成绩。作为负责人承担多项国家自然基金面上项目及部省级项目的研究。在Journal of Dental Research、Oral Oncology、ACS Nano、International Journal of Cancer、Biochemical Journal和Human Genetics等SCI源刊发表第通讯/第一作者论文二十余篇。获科技进步奖3项,相关研究获授权发明专利2项。作为副主编编撰《基于病案的口腔医学临床思维培养》、作为主编助理参编国家规划教材《口腔黏膜病学》(第4、5版)以及《口腔黏膜病科诊疗与操作常规》(第1版)。

研究领域:

1. 课题名称《口腔黏膜癌变机理及其防治》

类别:四川省杰出青年科技人才

2. 课题名称《新长链非编码RNA ORAOV1-B促进口腔黏膜癌变的机制及潜在的临床意义研究》

类别:国家自然科学基金面上项目

3. 课题名称《miR-450a通过转录后沉默和去甲基化双重调控细胞周期和凋亡促进口腔白斑发展的作用研究》

类别:国家自然科学基金面上项目

4. 课题名称《ORAOV1蛋白家族新成员在口腔黏膜癌变发生发展中的作用及其机制的研究》

类别:国家自然科学基金面上项目

5. 课题名称《口腔黏膜癌变过程中的多分子事件》

类别:国家自然科学基金面上项目

6. 课题名称《新型肿瘤标志物在癌病筛查和诊断中的应用研究》

类别:国家自然科学基金面上项目

7. 课题名称《ORAOV1 调控口腔黏膜癌变机理及以ORAOV1 为靶标防止口腔黏膜癌变的应用基础研究》

类别:国家自然科学基金面上项目

论文/著作:

1. Zihao Wei#, Yun Wang#, Lu Jiang#*, Ning Ji, Ying Wang, Fangman Chen, Taiwen Li, Jing Li, Hao Xu, Xin Zeng*, Qianming Chen*. miR-223 regulates oral squamous cell carcinoma metastasis through the Wnt/β-catenin signaling pathway. Oral Oncology. 2020 Aug 18;109:104941. doi: 10.1016/j.oraloncology.2020.104941. Online ahead of print.

2. Honglin Liao, Yuxue Luo, Li Long, Jiakuan Peng, Xuemei Qiu, Peiyang Yuan, Hao Xu*, Lu Jiang*. Anxiety and oral lichen planus. Oral Disease. 2020 Jul 22. doi: 10.1111/odi.13569. Online ahead of print.

3. Peiyao Wu, Shuhan Luo, Tao Zhou, Rui Wang, Xuemei Qiu, Peiyang Yuan, Yuqing Yang, Qi Han*, and Lu Jiang*. Possible Mechanisms Involved in the Cooccurrence of Oral Lichen Planus and Hashimoto’s Thyroiditis. Mediators of Inflammation. 2020 Feb 4; 2020:6309238. doi: 10.1155/2020/6309238.

4. Guoli Tian, Yuye Liang, Zihao Wei, Xuemei Qiu, Peiyang Yuan, Xin Zeng, Xinhua Liang*, Lu Jiang*, Qianming Chen*. Successful treatment of milia en plaque on the lip using microwave thermotherapy. The Journal of Dermatology. 2020 Apr;47(4):e128-e129. doi: 10.1111/1346-8138.15249. Epub 2020 Feb 11.

5. Zeng D, Xu H, Ji N, Li J, Zhou M, Dan H, Zhou Y, Zeng X, Jiang L*, Chen Q*. In situ measurement of miR-138 expression in oral squamous cell carcinoma tissue supports the role of this microRNA as a tumor suppressor. J Oral Pathol Med. 2019 Nov;48(10):911-918.

6. Jinli Liu, Fangman Chen, Zihao Wei, Min Qiu, Zheru Li, Hongxia Dan, Qianming Chen, Lu Jiang*. Evaluating the efficacy of pentoxifylline in the treatment of oral submucous fibrosis: a meta-analysis. Oral Diseases. 2018 Jul;24(5):706-716.

7. Zihao Wei, Qianqian Hou, Heng Xu, Qianming Chen,Lu Jiang*;Evidence of genetic factors involved in oral lichen planus pathogenesis. Oral Diseases. 2018 Jul;24(5):864-865.

8. Zhao, Hang; Feng, Hui; Liu, Dongjuan; Liu, Jiang; Ji, Ning; Chen, Fangman; Luo, Xiaobo; Zhou, Yu; Dan, Hongxia; Zeng, Xin; Li, Jing; Sun, Congkui; Meng, Jinyu; Ju, Xiao-Jie; Zhou, Min; Yang, Hanshuo; Li, Longjiang; Liang, Xinhua; Chu, Liang-Yin; Jiang, Lu*; He, Yang; Chen, Qianming. Self-Assembling Monomeric Nucleoside Molecular Nanoparticles Loaded with 5-FU Enhancing Therapeutic Efficacy against Oral Cancer. ACS Nano. 2015, 9 (10), 9638–9651.

9. Ji N, Jiang L*, Deng P, Xu H, Chen F, Liu J, Li J, Liao G, Zeng X, Lin Y, Feng M, Li L, Chen Q. Synergistic effect of honokiol and 5-fluorouracil on apoptosis of oral squamous cell carcinoma cells. J Oral Pathol Med. 2017 Mar;46(3):201-207.

10. Chen F, Xu H, Liu J, Cui Y, Luo X, Zhou Y, Chen Q, Jiang L*. Efficacy and safety of nucleoside antiviral drugs for treatment of recurrent herpes labialis: a systematic review and meta-analysis. J Oral Pathol Med. 2017 46:561-568.

11. Y Cui, H Xu, F Chen, J Liu, L Jiang*, Y Zhou,Qianming Chen. Efficacy evaluation of clonazepam for symptom remission in burning mouth syndrome: a meta-analysis. Oral Diseases. 2016 Sep;22(6):503-11

12. Luo X, Feng H, Jiang L*, Chen Q. Abnormal uterine bleeding induced by glucocorticoid treatment for pemphigus. Saudi Med J. 2016 Sep;37(9):1025-8.

13. Xiaodong Feng,# Yuchen Jiang,# Liang Xie,# Lu Jiang,# Jing Li, Chongkui Sun, Hao Xu, Ruinan Wang, Min Zhou, Yu Zhou, Hongxia Dan, Zhiyong Wang, Ning Ji, Peng Deng, Ga Liao, Ning Geng, Yun Wang, Dunfang Zhang, Yunfeng Lin, Ling Ye, Xinhua Liang, Longjiang Li, Gang Luo, Mingye Feng, Juan Fang, Xin Zeng #,Zhi Wang#, and Qianming Chen. Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma. J Exp Clin Cancer Res. 2016 Feb 19;35:35. doi: 10.1186/s13046-016-0309-z

14. Zhao X, Liu D, Wang L, Wu R, Zeng X, Dan H, Ji N, Jiang L*, Zhou Y, Chen Q. RNAi-mediated downregulation of oral cancer overexpressed 1 (ORAOV1) inhibits vascular endothelial cell proliferation, migration, invasion, and tube formation. J Oral Pathol Med. 2016 Apr;45(4):256-61.

15. Ma H, Yang H, Zhou Y, Jiang L*. Molluscum Contagiosum on the Lip. J Craniofac Surg. 2015 Oct;26(7):e681-2.

16. Li J, Guo Y, Feng X, Wang Z, Wang Y, Deng P, Zhang D, Wang R, Xie L, Xu X, Zhou Y, Ji N, Hu J, Zhou M, Liao G, Geng N, Jiang L*, Wang Z, Chen Q. Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells. J Cancer Res Clin Oncol. 2012 Apr;138(4):563-71.

17. Zhou Y, Zhu X, Lu R, Dan H, Wang F, Wang J, Li J, Feng X, Wang H, Ji N, Zhou M, Zeng X, Jiang L*, Chen Q. Vesicular stomatitis virus matrix protein (VSVMP) inhibits the cell growth and tumor angiogenesis in oral squamous cell carcinoma. Oral Oncol. 2012 Feb;48(2):110-6.

18. Jiang L#, Dai Y, Liu X, Wang C, Wang A, Chen Z, Heidbreder CE, Kolokythas A, Zhou X. Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. Hum Genet. 2011;129(2):189-97.

19. Jiang L#, Liu X, Kolokythas A, Yu J, Wang A, Heidbreder CE, Shi F, Zhou X. Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. International Journal of Cancer. 2010 Aug 1;127(3):505-12.

20. Jiang L#, Liu X, Chen Z, Jin Y, Heidbreder CE, Kolokythas A, Wang A, Dai Y, Zhou X. MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. Biochemical Journal. 2010 Nov 15;432(1):199-205.

21. Jiang L#, Zeng X, Wang Z, Ji N, Zhou Y, Liu X, Chen Q. Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and apoptosis in cervical cancer HeLa cells. Molecular Cancer. 2010 Jan 28;9:20.

22. Jiang L#, Yang HS, Wang Z, Zhou Y, Zhou M, Zeng X, Chen QM. ORAOV1-A correlates with poor differentiation in oral cancer. Journal of Dental Research. 2009 May;88(5):433-8.

23. Jiang L#, Ji N, Zhou Y, Li J, Liu X, Wang Z, Chen Q, Zeng X. CAL 27 is an oral adenosquamous carcinoma cell line. Oral Oncol. 2009 Nov;45(11):e204-7.

24. Jiang L#, Zeng X, Wang Z, Chen Q. Cell line cross-contamination: KB can no longer be used as an OSCC cell line. Eur J Oral Sci. 2009 Feb;117(1):90-1.

25. Jiang L#, Zeng X, Yang H, Wang Z, Shen J, Bai J, Zhang Y, Gao F, Zhou M, Chen Q. Oral cancer overexpressed 1 (ORAOV1): A regulator for the cell growth and tumor angiogenesis in oral squamous cell carcinoma. International Journal of Cancer. 2008 Oct 15;123(8):1779-86.

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