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博导

胡涛

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姓名:胡涛

职称:教授

职务:四川大学华西口腔医学院口腔预防科/教研室主任;四川大学发展规划处副处长

所在学系:口腔内科学系

研究生导师类别:博导

电子邮箱:hutao@scu.edu.cn

办公地址:四川大学华西口腔医学院医技楼口腔预防教研室

研究方向:牙菌斑生物膜的致病机制、牙髓干细胞的损伤修复、细胞发育和再生研究、口腔公共卫生、口腔常见疾病临床防治研究

教育背景:

1985.09-1991.07 华西医科大学口腔医学院 学士

1994.09-1997.07 华西医科大学口腔医学院 硕士

2002.09-2005.07 四川大学华西口腔医学院 博士

工作经历与学术任职:

1991.07-2007.07 留校历任助教(住院医师)、讲师(主治医师)、副教授(副主任医师)、教授(主任医师);

2006.09-今 博士生导师(副教授破格);

2017.09-今 任四川大学科研院重大项目和基地管理部副部长(副处长)

2013年-至今International Endodontic Journal 编委

2018年-至今四川省口腔医学会口腔预防专业委员会 主任委员

2012.04-2016.04四川省口腔医学会牙体牙髓专业委员会 主任委员

个人荣誉:

2010年获宝钢优秀教师奖

2010年入选四川省卫生厅学术和技术带头人

2010年入选四川省人事厅学术和技术带头人后备人选

2005年入选教育部新世纪优秀人才支持计划

获奖:

2017年获四川省科学技术进步奖一等奖

2016年获国家科学技术进步奖二等奖

2011年获四川省科技技术进步奖二等奖

22006年获教育部科学技术进步奖一等奖

2005年获四川省科学进步奖二等奖

2004年获教育部科学技术进步奖一等奖

2003年获中华医学科技奖三等奖

2002年获教育部科学技术进步奖一等奖

研究领域负责人:

1.课题名称《牙菌斑生物膜胞外多糖中间体结构的转换模式及其调控机制研究》类别:国家自然科学基金面上项目

2. 课题名称《RhoA对牙髓干细胞迁移过程中干性维持的调控机制研究》类别:国家自然科学基金

3. 课题名称《致龋微生物生物膜胞外多糖基质双向调控防龋效应的分子机制研究》类别:973前期计划

4. 课题名称《咀嚼力激活Rho/ROCK通路对牙髓干细胞修复机能的调控效应研究干预》类别:国家自然科学基金

5. 课题名称《干预变形链球菌vicRKX信号通路对生物膜糖代谢平衡的影响研究》类别:国家自然科学基金

6. 课题名称《牙髓干细胞迁移-分化时相特征及其"交互对话"研究》类别:国家自然科学基金

7. 课题名称《牙面生物膜细菌群体效应在龋病防治方面的分子机制研究》类别:国家自然科学基金

8. 课题名称《牙髓根尖周病临床路径和诊疗新标准的临床研究》类别:卫生部重点项目

主研:

1. 课题名称《基于成体/多能干细胞的牙功能组织模块构建及转化研究》类别:重点研发计划

2. 课题名称《牙发生发育分子机理及牙齿再生研究》类别:973计划

论文/著作论文:

(近五年主要研究方向代表作)

1. Hong Chen* , Yingming Yang , Michael D Weir , Quan Dai , Lei Lei, Negar Homayounfar, Thomas W Oates, Kai Yang, Ke Zhang, Tao Hu(corresponding author) , Hockin H K Xu(corresponding author). Regulating Oral Biofilm from Cariogenic State to Non-Cariogenic State via Novel Combination of Bioactive Therapeutic Composite and Gene-Knockout. Microorganisms. 2020 Sep 13;8(9):E1410. doi: 10.3390/microorganisms8091410.

2. Mingming Li*,Zhiwu Wu*,Rui Zhang(corresponding author),Lei Lei,Tao Hu(corresponding author). Comparison of oral health behaviour between dental and non-dental undergraduates in a university in southwestern China——exploring the future priority for oral health education. BMC Oral Health. April 2020. DOI: 10.21203/rs.3.rs-22269/v3.

3. Chen, Hong*, Zhang, Rui*, Cheng, Ran, Xu, Ting, Zhang, Tao, Hong, Xiao, Zhao, Xing, Wu, Yunyun, Cheng, Li, and Hu, Tao(corresponding author). "Gingival Bleeding and Calculus among 12-year-old Chinese Adolescents: A Multilevel Analysis." BMC Oral Health 20.1 (2020): 147.

4. Chen, H*; Tang, YH*; Weir, MD; Gao, JH; Imazato, S; Oates, TW; Lei, L; Wang, SP (corresponding author); Hu T (corresponding author); Xu, HHK (corresponding author). Effects of S. mutans gene-modification and antibacterial monomer dimethylaminohexadecyl methacrylate on biofilm growth and acid production. Dental Materials. 2020 Feb 36 (2): 296-309. DOI: 10.1016/j.dental.2019.12.001.

5. Chen, H*; Zhang, B; Weir, MD; Homayounfar, N; Fay, GG; Martinho, F; Lei, L; Bai, YX (corresponding author); Hu T (corresponding author); Xu, HHK (corresponding author). S. mutans gene-modification and antibacterial resin composite as dual strategy to suppress biofilm acid production and inhibit caries. Journal of Dentistry. 2020 Feb; 93:103278. DOI: 10.1016/j.jdent.2020.103278.

6. Lei L*, Zhang B*, Mao M*, Chen H, Wu S, Deng Y, Yang Y(corresponding author)., Zhou H(corresponding author)., Hu T (corresponding author).Carbohydrate Metabolism Regulated by Antisense vicR RNA in Cariogenicity. Journal of Dental Research. 2020 Feb;99(2):204-213. doi: 10.1177/0022034519890570. Epub 2019 Dec 10.

7. Xu J*, Wang L, Li H, Yang T, Zhang Y, Hu T (corresponding author), Huang Z(corresponding author), Chen Y(corresponding author). Shox2 regulates osteogenic differentiation and pattern formation during hard palate development in mice. J Biol Chem. 2019 Nov 29;294(48):18294-18305. doi: 10.1074/jbc.RA119.008801. Epub 2019 Oct 24.

8. Lei Lei*, Yang Yan, Yang Yingming, Wu Shizhou, Ma Xinrong, Mao Mengying (corresponding author), Tao Hu (corresponding author). Mechanisms by Which Small RNAs Affect Bacterial Activity. Journal of Dental Research. 2019 Nov;98(12):1315-1323. DOI: 10.1177/0022034519876898.

9. Cheng L*, Liu W*, Zhang T, Xu T, Su YX, Yuan B, Yang YM (corresponding author), Hu T (corresponding author). Evaluation of the effect of a toothpaste containing Pudilan extract on inhibiting plaques and reducing chronic gingivitis: A randomized, double-blinded, parallel controlled clinical trial. J Ethnopharmacol. 2019 Apr 10:111870. doi: 10.1016/j.jep.2019.111870.

10. Jue Xu*, Zhen Huang, Weiqi Wang, Xiaoqian Tan, Hua Li, Yanding Zhang, Weidong Tian, Tao Hu (corresponding author), and Yiping Chen (corresponding author). FGF8 signaling alters the osteogenic cell fate in the hard palateLeukoplakia-Associated Fibroblasts to Candida albicans. J Dent Res, 2018 May;97(5):589-596. Epub 2018 Jan 17. doi: 10.1177/0022034517750141.

11. Cheng R*, Feng Y*, Zhang R, Liu W, Lei L, Hu T(corresponding author), The extent of pyroptosis varies in different stages of apical periodontitis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2018 Jan;1864(1):226-237. doi: 10.1016/j.bbadis.2017.10.025. Epub 2017 Oct 21.

12. Cheng R*, Liu W, Zhang R, Feng Y, N.A. Bhowmick(corresponding author), Hu T(corresponding author). Porphyromonas gingivalis-Derived Lipopolysaccharide Combines Hypoxia to Induce Caspase-1 Activation in Periodontitis. Front Cell Infect Microbiol. 2017 Nov 14;7:474. doi: 10.3389/fcimb.2017.00474. eCollection 2017.

13. Wang Y*, Guo LY*, Fang HZ, Zou WL, Yang YM, Gao Y, Yang H(corresponding author), Hu T (corresponding author). An in vitro study on the efficacy of removing calcium hydroxide from curved root canal systems in root canal therapy. Int J Oral Sci. 2017 Jun;9(2):110-116. doi: 10.1038/ijos.2017.14. Epub 2017 Jun 23

14. Yang H*, Shu YX*, Wang LY, Zou WL, Guo LY, Shao MY, Gao QH (corresponding author), Tao Hu (corresponding author). Effect of cyclic uniaxial compressive stress on human dental pulp cells in vitro, Connect Tissue Res. 2018 May;59(3):255-262. doi: 10.1080/03008207.2017.1367773. Epub 2017 Sep 8..

15. Xu J*, Shao MY*, Pan HY, Lei L, Liu T, Cheng L, Hu T (corresponding author), Dummer PM. A proposal for using contralateral teeth to provide well-balanced experimental groups for endodontic studies. Int Endod J. 2016 Oct;49(10):1001-8. doi: 10.1111/iej.12553. Epub 2015 Oct 16.

16. Yang YM*, Guo B, Guo LY, Yang Y, Hong X, Pan HY, Zou WL (corresponding author), Hu T (corresponding author). CBCT-Aided Microscopic and Ultrasonic Treatment for Upper or Middle Thirds Calcified Root Canals. Biomed Res Int. 2016;2016:4793146. doi: 10.1155/2016/4793146. Epub 2016 Jul 25.

17.著作

1. Zhou XD, Ye L, Li JY, Shi WY, Hu T, Cheng L, Zheng LW, Wang CL, Xu X, Zhou Y, Liu YL, Wang RK, Xu Hockin H.K., Yang L, Li BE, Wang S, Zhang YR, Peng L, Hong X, Zou L, Huang XL, Guo Q, Ren B, Li YQ. Dental Caries: Principles and Management. German; Springer-Verlag Berlin and Heidelberg GmbH & Co. KG. 2015 October; doi: 10.1007/978-3-662-47450-1.

2. Tao Hu, Ran Cheng, Meiying Shao, Hui Yang, Ru Zhang, Qianhua Gao and Liyang Guo (2010). Application of Finite Element Analysis in Root Canal Therapy, Finite Element Analysis, David Moratal (Ed.), ISBN: 978-953-307-123-7, InTech, Available from: http://www.intechopen.com/books/finite-element-analysis/application-offinite-element-analysis-in-root-canal-therapy

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