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人才培养

博导

冯晓东

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姓名:冯晓东

职称:研究员

所在学系:口腔基础医学系

研究生导师类别:博导

电子邮箱:fengxiaodong84@126.com

办公地址:四川省成都市人民南路三段14号华西口腔医技楼,B806

研究方向:细胞生长调控,G蛋白和GPCR,Hippo-YAP,头颈部肿瘤,疾病精准治疗

工作经历

2019至今四川大学,华西口腔医学院,口腔疾病研究国家重点实验室研究员

2016-2019加州大学圣地亚哥分校(UCSD),Moores Cancer Center博士后(导师:J. Silvio Gutkind, Ph.D. 美国医学院院士)

2013-2015美国国立卫生院(NIH),国立牙颅颌研究(NIDCR)博士后(导师:J. Silvio Gutkind, Ph.D. 美国医学院院士)

教育背景

2010-2013美国国立卫生院(NIH),国立牙颅颌研究(NIDCR)联合培养博士(导师:J. Silvio Gutkind, Ph.D. 美国医学院院士)

2008-2013四川大学华西口腔医学院,口腔基础医学博士研究生(硕博连读-导师:陈谦明 教授,长江学者,杰出青年基金获得者)

2004-2008四川大学生命科学院生物技术基地班(学士学位)

学术任职

2020.08-至今 四川省口腔医学学会口腔生物学专委会 副主任委员

2020.03-至今 国际牙医师学院(ICD) 中国区院士

个人荣誉、获奖

2013年 研究员杰出研究奖(FARE),NIH

2017年 第十四批国家“海外高层次人才引进计划”青年项目入选者

2020年 四川省“海外高层次人才引进计划”青年项目入选者

研究领域

2019-2023,“海外高层次人才引进计划”启动经费(300万,中组部)

2019-2023,四川大学华西口腔医(学)院引进人才科研启动经费(150万)

2019-2023,四川大学引进人才科研启动经费(150万)

论文/著作

1. Jiang Y, Li T, Wu Y, Xu H, Xie C, Dong Y, Zhong L, Wang Z, Zhao H, Zhou Y, Li J, Ji N, Zeng X, Feng X, Chen Q. GPR39 Overexpression in OSCC Promotes YAP-Sustained Malignant Progression. J Dent Res. 2020 Apr 23:22034520915877.

2. Goto Y, Ando T, Izumi H, Feng X, Arang N, Gilardi M, Wang Z, Ando K, Gutkind JS. Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis. Oncogene. 2020 Mar 23.

3. Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019 Mar 20.

4. Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E. Direct targeting of Gαq and Gα11 oncoproteins in cancer cells. Sci Signal. 2019 Mar 19;12(573).

5. Feng X, Arang N, Rigiracciolo D, Lee J, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini, M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS. A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell. 2019 Mar 18;35(3):457-472.

6. Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018 Jul 9;9(1):2372.

7. O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS. Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK. Sci Signal. 2017 Jun 20; 10(484).

8. Feng X, Jiang Y, Xie L, Jiang L, Li J, Sun C, Xu H, Wang R, Zhou M, Zhou Y, Dan H, Wang Z, Ji N, Deng P, Liao G, Geng N, Wang Y, Zhang D, Lin Y, Ye L, Liang X, Li L, Luo G, Feng M, Fang J, Zeng X, Wang Z, Chen Q. Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma. J Exp Clin Cancer Res. 2016 Feb 19;35:35.

9. Luo X, Xu H, He M, Han Q, Wang H, Sun C, Li J, Jiang L, Zhou Y, Dan H, Feng X, Zeng X, Chen Q. Accuracy of autofluorescence in diagnosing oral squamous cell carcinoma and oral potentially malignant disorders: a comparative study with aero-digestive lesions. Sci Rep. 2016 Jul 15;6:29943.

10. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Chen M, Weinstein SL, Taylor SS, Molinolo AA, and Gutkind JS. Inactivation of a Gαs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nature Cell Biology. 2015 Jun;17(6):793-803.

11. Li J, Feng X, Sun C, Zeng X, Xie L, Xu H, Li T, Wang R, Xu X, Zhou X, Zhou M, Zhou Y, Dan H, Wang Z, Ji N, Deng P, Liao G, Geng N, Wang Y, Zhang D, Lin Y, Ye L, Liang X, Li L, Luo G, Jiang L, Wang Z, Chen Q. Associations between proteasomal activator PA28γ and outcome of oral squamous cell carcinoma: Evidence from cohort studies and functional analyses. EBioMedicine. 2015 Jul 10;2(8):851-8.

12. Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell. 2014 Jun 16;25(6):831-45. (封面论文)

13. Feng X, Chen Q, Gutkind JS. Oncotargeting G proteins: The Hippo in the room. Oncotarget. 2014 Nov 30;5(22):10997-9.

14. Vaqué JP, Dorsam RT, Feng X, Iglesias-Bartolome R, Forsthoefel DJ, Chen Q, Debant A, Seeger MA, Ksander BR, Teramoto H, Gutkind JS. A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing GPCR-initiated mitogenic signals. Mol Cell. 2013 Jan 10;49(1):94-108.

15. Zhou Y, Zhu X, Lu R, Dan H, Wang F, Wang J, Li J, Feng X, Wang H, Ji N, Zhou M, Zeng X, Jiang L, Chen Q. Vesicular stomatitis virus matrix protein (VSVMP) inhibits the cell growth and tumor angiogenesis in oral squamous cell carcinoma. Oral Oncol. 2012 Feb;48(2):110-6.

16. Li J, Guo Y, Feng X, Wang Z, Wang Y, Deng P, Zhang D, Wang R, Xie L, Xu X, Zhou Y, Ji N, Hu J, Zhou M, Liao G, Geng N, Jiang L, Wang Z, Chen Q. Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells. J Cancer Res Clin Oncol. 2012 Apr; 138(4):563-71.

17. Li J, Gong C, Feng X, Zhou X, Xu X, Xie L, Wang R, Zhang D, Wang H, Deng P, Zhou M, Ji N, Zhou Y, Wang Y, Wang Z, Liao G, Geng N, Chu L, Qian Z, Wang Z, Chen Q. Biodegradable thermosensitive hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma xenografts. PLoS One. 2012;7(4):e33860.

18. Wang Z, Feng X, Li J, Ji N. Biomarker identification in oral cancer by using proteomics. Interface Oral Health Science 2009. 2010 pp: 167-168.

19. Wang Z, Zhang B, Jiang L, Zeng X, Chen Y, Feng X, Guo Y, Chen Qianming. RACK1, an excellent predictor for poor clinical outcome in oral squamous carcinoma, similar to Ki67. Eur J Cancer. 2009 Feb; 45(3): 490-6.

20. Wang Z, Feng X, Liu X, Jiang L, Zeng X, Ji N, Li J, Li L, Chen Q. Involvement of potential pathways in malignant transformation from Oral Leukoplakia to Oral Squamous Cell Carcinoma revealed by proteomic analysis. BMC Genomics. 2009 Aug 19;10(1): 383.

21. Zhou C, Zhou Y, Li J, Zhang Y, Jiang L, Zeng X, Feng X, Wang Z. The Arg194Trp polymorphism in the X-ray repair cross-complementing group 1 gene as a potential risk factor of oral cancer: a meta-analysis. Tohoku J Exp Med. 2009 Sep; 219(1): 43-51.

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