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硕导

李明云

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姓名:李明云

职称:副教授

所在学系:口腔基础医学系

研究生导师类别:硕导

电子邮箱:limingyun@scu.edu.cn

办公地址:四川省成都市人民南路三段14号华西口腔医院6楼604

研究方向:龋病的防治机制,微生物免疫防治,口腔生物学和材料学

个人简介:

2007年9月进入四川大学华西口腔医学院硕博连读研究生学习,师从周学东教授,2012年6月博士研究生毕业,并留校工作。2016年9月至今为四川大学华西口腔医学院口腔基础医学系副教授。从2007年入校就读研究生开始就致力于龋病相关口腔微生物基础研究和口腔微生物代谢组学相关研究;2010-2012年,作为国家留学基金委公派研究生,赴美国印第安纳大学普渡大学印第安纳波利斯分校进行联合培养博士研究,主要从事烟草中尼古丁对口腔微生物致病机理研究,目前已发表SCI论文30余篇,其中第一作者及通讯作者21篇,中文一作及通讯作者13篇,待发表多篇。

担任biomed research international (microbiology)以及frontiers in oral health(Oral hygiene and oral health policy)杂志副主编。担任多个中英文杂志审稿人,比如Archives of Oral Biology, International Journal of Oral Science, International Journal of Nanomedicine,Biomed Research International,Tobacco induced diseases, Microbial pathogenesis,Journal of Visualized Experiments,Frontiers in Microbiology以及《华西口腔医学杂志》、《国际口腔医学杂志》和《口腔疾病防治》等。

目前为中国微生物学会终身会员,中华口腔医学会口腔生物医学专委会委员,四川省口腔医学会生物专委会委员

曾获四川大学青年骨干教师奖,“探究式-小班化”教学质量优秀奖,大学生课外科技实践活动优秀指导教师等奖项。

研究领域:

1.国家自然科学基金青年基金:尼古丁对变异链球菌糖代谢信号通路的调控作用研究

2.口腔疾病研究国家重点实验室自主课题:变异链球菌丙氨酸消旋酶功能研究

3.四川大学“2020年度基础研究培育专项”金黄色葡萄球菌与白色念珠菌协同逃逸中性粒细胞胞外诱捕网的机制研究

论文/著作:

1. Li M, Huang R, Zhou X, Zhang K, Zheng X, Gregory RL*. Effect of nicotine on dual species biofilms of Streptococcus mutans and Streptococcus sanguinis. FEMS Microbiology Letters, 350:125-132, 2014.

2. Li M, Huang R, Zhou X, Gregory RL*. Role of sortase in Streptococcus mutans under the effect of nicotine. International Journal of Oral Science, 5:206-211, 2013.

3. Wei Qiu ◄, Xin Zheng◄, Yuan Wei, Xuedong Zhou, Keke Zhang, Shida Wang, Lei Cheng, Yan Li , Biao Ren, Xin Xu, Yuqing Li, Mingyun Li*. D-alanine Metabolism is Essential for Growth and Biofilm Formation of Streptococcus mutans. Molecular Oral Microbiology. 2016 Oct; 31(5): 435-44.

4. Yutao Yang#, Shiyu Liu#, Yuanli He, Zhu Chen*, Mingyun Li*. Effect of LongZhang Gargle on biofilm formation and acidogenicity of Streptococcus mutans in vitro. Biomed research international. Volume 2016 (2016), Article ID 5829823

5. Yuan Wei, Wei Qiu, Xuedong Zhou, Xin Zheng, Keke Zhang, Shida Wang, Yuqing Li, Lei Cheng, Jiyao Li, Xin Xu#, Mingyun Li#. Alanine racemase is essential for the growth and interspecies competitiveness of Streptococcus mutans. International Journal of Oral Science (2016) 8, 231–238

6. Mingyun Li*, Ruijie Huang, Xuedong Zhou, Wei Qiu, Xin Xu, and Richard L. Gregory*. Effect of nicotine on cariogenic virulence of Streptococcus mutans. Folia microbiologica. 2016. Nov; 61(6):505-512.

7. Shiyu Liu, Wei Qiu, Keke Zhang, Xuedong Zhou, Biao Ren, Xin Xu, Lei Cheng*, Mingyun Li*. Nicotine enhances interspecies relationship between Streptococcus mutans and Candida albicans. BioMed Research International. Volume 2017 (2017), Article ID 7953920, 9 pages

8. Shiyu Liu, Tianmu Wu, Xuedong Zhou, Bo Zhang, Sibei Huo, Yutao Yang, Keke Zhang, Lei Cheng, Xin Xu, Mingyun Li*. Nicotine is a risk factor for dental caries: an in vivo study. Journal of Dental Science. (2018) 13, 30-36.

9. Shiyu Liu#, Yuan Wei#, Xuedong Zhou, Keke Zhang, Xian Peng, Biao Ren, Vivian Chen, Lei Cheng*, Mingyun Li*. Function of alanine racemase in the physiological activity and cariogenicity of Streptococcus mutans. Scientific Reports. 2018 Apr 13;8(1):5984.

10. Yixin Zhang, Jinxiu He, Bing He, Ruijie Huang*, Mingyun Li*. Effect of tobacco on periodontal disease and oral cancer. Tobacco Induced Diseases. 2019; 17(May): 40.

11. Qingsong Jiang, Xuedong Zhou, Lei Cheng, Mingyun Li* The Adhesion and Invasion Mechanisms of Streptococci. Current Issues in Molecular Biology. 2019 Jun 5;32:521-560.

12. Jiayi Wu, Mingyun Li*, Ruijie Huang*. The effect of smoking on caries-related microorganisms. Tobacco Induced Diseases. 2019; 17(April): 32.

13. Xiao Guo, Shiyu Liu, Xuedong Zhou, Hongying Hu, Keke Zhang, Xinmei Du, Xian Peng, Biao Ren, Lei Cheng*, Mingyun Li*. Effect of D-cysteine on dual-species biofilms of Streptococcus mutans and Streptococcus sanguinis. Scientific Reports. 2019, 9:6689.

14. Dan Liu, Xian Peng, Suping Wang, Qi Han, Bolei Li, Xinxuan Zhou, Biao Ren, Huakun Xu, Michael D. Weir, Mingyun Li*, Xuedong Zhou*, Lei Cheng*. A novel antibacterial resin-based root canal sealer modified by Dimethylaminododecyl Methacrylate. Scientific Reports. 2019, 9:10632.

15. Sanjay Kumar Tiwari#,Xiao Guo#, Yannan Huang#, Xuedong Zhou, Huakun (Hockin) Xu, Biao Ren, Xian Peng, Michael D. Weir, Mingyun Li*, Lei Cheng*. The inhibitory effect of quaternary ammonium salt on bacteria in root canal. Scientific Reports. 2019, 9:12463.

16. Liu S#, Chen M#, Wang Y, Zhou X, Peng X, Ren B, Li M*, Cheng L*. Effect of Veillonella parvula on the physiological activity of Streptococcus mutans. Archives of Oral Biology. 2020, 109: 104578.

17. Xiaoyu Huang, Wen Zhou, Xuedong Zhou, Yao Hu, Pengfei Xiang, Bolei Li, Bangcheng Yang, Xian Peng, Biao Ren, Mingyun Li*, Lei Cheng*. Effect of Novel Micro-Arc Oxidation Implant Material on Preventing Peri-Implantitis. Coatings, 2019, 9(11),691.

18. Jiang Y,Zhou X,Cheng L*,Li M*. The impact of smoking on subgingival microflora: from periodontal health to disease. Frontier in Microbiology. 2020,11:66.

19. Sanjay Kumar Tiwari#, Suping Wang#, Yannan Huang#, Xuedong Zhou, Hockin H. K. Xu, Biao Ren, Xian Peng, Michael D. Weir, Mingyun Li *, Lei Cheng * The antibacterial effects of quaternary ammonium salts in the presence of inhibitors in root canals. Coatings 2020, 10(2), 181

20. Weidan Luo#, Yannan Huang#, Xuedong Zhou, Qi Han, Xian Peng, Biao Ren, Jiyao Li, Mingyun Li*, Lei Cheng*. The effect of disaggregated nano-hydroxyapatite on oral biofilm in vitro. Dent Mater. 2020, 36(7): e207-e216.

21. Jinzhao Yu#, Xiaoyu Huang#, Xuedong Zhou, Qi Han, Wen Zhou, Jingou Liang, Hockin H. K. Xu, Biao Ren, Xian Peng, Michael D. Weir, Mingyun Li*, Lei Cheng*. Anti-caries effect of resin infiltrant modified by quaternary ammonium monomers. Journal of Dentistry. 2020, 97:103355.

22. 刘恩言,李明云*.茶多酚类化合物在牙本质粘接中的应用研究进展.国际口腔医学杂志.2020(接受)

23. 刘恩言,贺兵,李明云*. EGCG预防和治疗口腔癌的研究进展.口腔疾病防治。2020,28(7):468-471.

24. 崔娅,贺兵,李明云*。磷脂酰肌醇3-激酶/蛋白激酶B信号通路与口腔癌关系的研究进展。华西口腔医学杂志。2019,37:400-404.

25. 李琪婧,李晓虹,李佩莲,林夕秋,贺兵,李明云*。烟草对口腔微生物影响的研究进展。华西口腔医学杂志。2019,37:343-346.

26. 郭笑,杜信眉,程磊,周学东,李明云*。D-丙氨酸在细菌中的功能和代谢研究进展。口腔疾病防治。2019,27(4): 264–267.

27. 郭笑,邱伟,周学东,程磊,李明云*。变异链球菌丙氨酸消旋酶基因表达纯化及活性测定。口腔医学研究. 2018,34(6):597-600.

28. 王玉霞,周学东,李明云*.韦荣球菌与龋病和链球菌间的关系. 国际口腔医学杂志. 2017,44(2):195-199.

29. 刘诗雨, 田宓,石黎冉,潘韦霖,王一尧,李明云*.尼古丁和美卡拉明对牙周致病微生物的影响.国际口腔医学杂志,2017,44(4):421-425

30. 刘诗雨, 何金枝, 李明云*. 白假丝酵母菌与龋病关系的研究进展. 国际口腔医学杂志, 2017,44(1): 103-107.

31. 张博, 霍思蓓, 刘诗雨, 李明云*. 牙齿美白剂对口腔微生物影响的研究进展. 中华口腔医学杂志, 2016, 51(2): 114-118.

32. 邱伟, 周学东, 李明云*. 丙氨酸消旋酶最新研究进展. 国际口腔医学杂志,2016, 43(2): 228-232.

33. 康健, 李明云*. 茶多酚对牙龈卟啉单胞菌的体外抑菌活性研究. 华西口腔医学杂志. 2015,33:81-83.

34. 李明云, 郭强, 周学东,熊萍,贾向明,肖晓蓉,李伟,肖丽英*. 口腔常见放线菌代谢组学鉴定的初步研究. 华西口腔医学杂志, 2009, 27(4): 443-446.

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