WCSS Researchers Developed Extra- and Intracellular Bacteria-targeted Ferroptosis-related Bio-heterojunction for Diabetic Wound Repair
Researchers from West China School of Stomatology (WCSS), Sichuan University, have successfully devised and developed an engineered bio-heterojunction capable of inducing extra- and intracellular bacterial ferroptosis and hunger-triggered cell protection for bacteria-invaded diabetic cutaneous tissue regeneration. The research , published in the journal Advanced Materials (2023, 2305277), demonstrates a new type of material that displays effective anti-bacterial properties and cellular protection by regulating ferroptosis.
Flowchart of the preparation steps and procedure for FMG bio-HJ (F-bio-HJ) and the mechanism of extra-intracellular bacteria-targeted ferroptosis and hunger-triggered cell protection induced by F-bio-HJ.
Bacterial infection is considered one of the most prominent threats to public health, which occurs both intracellularly and extracellularly. However, intracellular pathogens are difficult to eliminate due to compromised host cell functions and immune escape. Nanomaterial-mediated ferroptosis has garnered considerable interest in the antibacterial field, as it invokes the disequilibrium of ion homeostasis and boosts lipid peroxidation in extra- and intracellular bacteria. However, current ferroptosis-associated antibacterial strategies indiscriminately pose damage to healthy cells, ultimately compromising their biocompatibility.
WCSS researchers report a novel engineered bio-heterojunction F-bio-HJ that can target both extracellular and intracellular bacterial ferroptosis, simultaneously triggering host cell protection through starvation and ultimately promoting diabetic wound healing.
Collectively, F-bio-HJ possesses three major characteristics, namely outstanding photothermal, photodynamic, chemical dynamic properties, highly efficient antibacterial performance, and starvation-triggered AMPK pathway-mediated cellular protection.
In summary, the proposed tactic markedly elevates the biocompatibility of therapeutic ferroptosis-mediated strategies and provides the design of bacteria-targeted bio-HJs to inspire versatile therapeutic strategies or drug candidates for multiple infectious diseases.
Prof. Ding Bai, Prof. Weizhong Yang (College of Biomedical Engineering), and Prof. Yi Deng (School of Chemical Engineering) are the co-corresponding authors. Dr. Wenyu Dai and Assoc. Prof. Rui Shu are the co-first authors.
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