WCSS Researchers Reveal the Immune Microenvironment Around Cutaneous Biosynthetic Scaffolds
Researchers from West China School of Stomatology (WCSS), Sichuan University have conducted the first study deciphering the overall immune microenvironment around cutaneous scaffold using scRNA-seq, showing that the microenvironment around scaffolds involves an intricate interplay of immune and cutaneous cells.
Biomaterials and devices implanted in the body have a broad spectrum of clinical applications like tissue regeneration and cell transplantation. Previous studies had often focused on certain types of immune cells rather than an overview of different immune cells in the microenvironment upon implantation of a material, which will aid in the comprehensive understanding of the immune responses elicited by scaffolds.
Researchers developed poly(lactic-co-glycolic acid)–fish collagen (PLGA-FC) hybrid electrospun scaffolds with three types of surface topography (random group, latticed group and aligned group). They explored the regenerative outcomes of these scaffolds in rat/mouse dorsal skin excisional wounds and evaluated their immunomodulatory properties. The aligned group displayed an adaptive immunity–dominant response and yielded the most desirable results among three scaffolds. Integrated analysis of three scaffolds suggested that T cells had modulatory effects on wound healing.
